2-Methylimidazole
2 Methylimidazole is an organic compound white or colorless solid that is highly soluble in polar organic solvents and water.
- Part number
- RXSOL-60-6910-025
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH₃C₃H₂N₂H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of drugs and is a ligand in coordination chemistry.
Technical specifications
Physical Properties:
| Melting Point | 142-143 °C lit. |
| Boiling Point | 267-268 °C lit. |
| Density | 1.0500 rough estimate |
| Vapour pressure | <1 mm Hg ( 0 °C |
| Refractive index | 1.4970 estimate |
| Flash Point | 155 °C |
| Solublity | 780g/l |
| Storage temprature | 2-8°C |
| pKa | 14.44±0.10 Predicted |
| Form | Crystalline Powder |
| Colour | White to light yellow |
| PH | 10.5-11.5 |
| Solublity | Soluble in water and ethanol |
Applications
2-Methylimidazole is used as a raw material for the preparation of nitroimidazole antibiotics, which is useful in combat anaerobic bacterial and parasitic infections. It acts as a ligand in coordination chemistry.
Dosage and directions
It is also employed as a hardener or accelerator for epoxy resin and auxiliary agent for textile dyes.
Characteristics and notes
Further, it acts as a catalyst for refolding of enhanced colored fluorescent protein. It is also useful as a building block in the synthesis of biologically active compounds. In addition to this, it is used as an active pharmaceutical ingredient intermediate such as metronidazole and dimetridazole.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | 2-Methylimidazole |
| Part Number | RXSOL-60-6910-025 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com | |
| Website | www.rxmraine.com |
| Chemical Name | CAS | EC number | Weight | Formula |
| 2-Methylimidazole | 693-98-1 | 211-765-7 | <= 100 % | C4H6N2 |
| Signal Word | Danger |
| Hazard Statements | H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. H351 Suspected of causing cancer. H360Df May damage the unborn child. Suspected of damaging fertility. |
| P280 Wear protective gloves.P305 + P351 + P338 | Wear eye protection/ face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Precautionary statements | P260 Do not breathe dust. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Classification of the substance or mixture | Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008. |
| Supplemental Hazard Statements | None |
| Other hazards | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| General advice | First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance. |
| If inhaled | After inhalation: fresh air. Call in physician. |
| Eye Contact | After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses. |
| Swallowed | After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise. |
| Skin Contact | In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately. |
| Inhalation | Remove patient to fresh air, keep warm and at rest and get medical assistance in necessary. |
| Ingestion | Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately. |
| Most important symptoms and effects, both acute and delaye | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Flammability | May be combustible at high temperature. |
| Suitable extinguishing media | Water Foam Carbon dioxide (CO2) Dry powder |
| Unsuitable extinguishing media | For this substance/mixture no limitations of extinguishing agents are given. |
| Special hazards arising from the substance or mixture | Carbon oxides Nitrogen oxides (NOx) Combustible. Development of hazardous combustion gases or vapours possible in the event of fire. |
| Further information | Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system. |
|
Hazardous combustion products |
Fire may cause the evolution of Sulphur oxides, nitrogen oxides. |
| Advice for firefighters | Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. |
| Protective Equipment | Use personal protective equipment. |
| Specific Hazards Arising from the Chemical |
Has a fire-promoting effect due to the release of oxygen. Ambient fire may liberate hazardous vapours. |
| Personal precautions, protective equipment and emergency procedures | Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. |
| Spillage | Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal. |
| Personal Protection | Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: Protective equipment see section 8. |
| Enviromental Precaution | Do not let product enter drains. |
|
Methods and materials for containment and cleaning |
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. |
| Advice on safe handling | Work under hood. Do not inhale substance/mixture. |
| Advice on protection against fire and explosion | Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. |
| Incompatible materials | Keep away from alkalis, strong oxidizing agents and metals. Provide containment walls of adequate capacity to hold any accidental spills. |
| Hygiene measures | Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. |
| Precautions for safe handling | For precautions see section 2.2. |
| Conditions for safe storage, including any incompatibilities | Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. |
| Storage conditions | Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. |
| Storage class | Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| Advice on general occupational hygiene | Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance. |
| Requirements for storage | Keep in cool and store under shade. |
| Exposure controls | No specific additional engineering controls are required. Provide good natural or artificial ventilation. |
| Engineering Control | Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. |
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles |
| Body Protection | Protective clothing. |
| Skin protection | This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L |
| Respiratory protection | Required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. |
| Other Protection Measure | Handle in accordance with good industrial hygiene and safety practice. |
| Control of environmental exposure | Do not let product enter drains. |
| Physical state | Powder |
| Colour | White |
| Odour | No data available |
| Odor Threshold | Not Applicable |
| pH | No data available |
| Melting Point | 142 - 143 °C - lit. |
| Boiling Point | 267 - 268 °C - lit. |
| Flash Point | No data available |
| Evaporation Rate | Not Applicable |
| Flammability (solid, gas) | No data available |
| Explosive limits | No Data Available |
| Upper/lower flammability or explosive limits | No data available |
| Autoignition temperature | No data available |
| Decomposition temperature | No data available |
| Viscosity,kinematic | No data available |
| Vapour pressure | 0,011 hPa at 50 °C |
| Density | 1,09 g/cm3 at 20 °C |
| Relative Vapour Density | 1,096 at 20 °C |
| Freezing point | No data available |
| Specific Gravity | No data available |
| Partition coefficient | Log Pow: 0,22 at 25 °C |
| Explosive properties | No data available |
| Solubility | 267 g/l at 20 °C |
| Ignition temperature | No information available. |
| Particle characteristics | No data available |
| Reactivity | The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. |
| Stability | The product is chemically stable under standard ambient conditions (room temperature) . |
| Possibility of hazardous reactions | Exothermic reaction with: Acid chlorides Acid anhydrides Strong oxidizing agents acids |
| Conditions to avoid | No data available |
| Incompatible materials | Strong oxidizing agents |
| Hazardous Polymerization | In the event of fire: see section 5 |
| Acute toxicity | LD50 Oral - Rat - male and female - 1.500 mg/kg (OECD Test Guideline 401) Acute toxicity estimate Oral - 1.500 mg/kg (Calculation method) Inhalation: No data available LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402) |
| Skin corrosion/irritation | Skin - Rabbit Result: Corrosive after 1 to 4 hours of exposure - 4 h (OECD Test Guideline 404) |
| Serious eye damage/eye irritation | Eyes - Rabbit Result: Corrosive (OECD Test Guideline 405) |
| Respiratory or skin sensitization | Local lymph node assay (LLNA) - Mouse Result: Does not cause skin sensitization. (OECD Test Guideline 429) |
| Carcinogenicity | Suspected of causing cancer. |
| Germ cell mutagenicity | Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: Micronucleus test Species: Mouse Application Route: Intraperitoneal Method: OECD Test Guideline 474 Result: negative Test Type: dominant lethal test Species: Mouse Application Route: Intraperitoneal Method: OECD Test Guideline 478 Result: negative |
| Reproductive toxicity | May damage the unborn child. Suspected of damaging fertility. |
| Specific target organ toxicity - single exposure | No data available |
| Special Remarks on other Toxi Effects on Humans | Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism. |
| Additional Information | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. RTECS: NI7175000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. |
| Persistence and degradability | Biodegradability aerobic - Exposure time 28 d Result: 67 % - Readily biodegradable. (OECD Test Guideline 301B) |
| Bioaccumulative potential | No data available |
| Toxicity to fish | Static test LC50 - Leuciscus idus (Golden orfe) - 190 mg/l - 96 h (DIN 38412) static test NOEC - Leuciscus idus (Golden orfe) - 100 mg/l - 96 h (DIN 38412) |
| Toxicity to daphnia and other aquatic invertebrates | Static test EC50 - Daphnia magna (Water flea) - 200 mg/l - 48 h (OECD Test Guideline 202) |
| Toxicity to algae | Static test EC50 - Desmodesmus subspicatus (green algae) - 256,3 mg/l - 72 h (DIN 38412) |
| Products Biodegradation | The methods for determining the biological degradability are not applicable to inorganic substances. |
| Mobility in soil | No Information available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. |
| Other adverse effects | No data available |
| Disposal methods | The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. |
| Contaminated packaging | Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. |
| Waste treatment Method | See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions. |
| UN number | ADR/RID: 3259 IMDG: 3259 IATA:3259 |
| UN proper shipping name |
ADR/RID:Amines, solid, corrosive, n.o.s. (2-Methylimidazole) IMDG:Amines, solid, corrosive, n.o.s. (2-Methylimidazole) IATA:Amines, solid, corrosive, n.o.s. (2-Methylimidazole) |
| Transport hazard class(es) | ADR/RID: 8 IMDG: 8 IATA: 8 |
| Packaging group | ADR/RID: III IMDG: III IATA: III |
| Environmental hazards | ADR/RID: No IMDG: No IATA: No |
| Special precautions for user | Tunnel restriction code : (C/E) |
| Further information | Not classified as dangerous in the meaning of transport regulations. |
| Transport in bulk according to IMOinstruments | No data available |
| Inventory status | Components are on the following inventories: Polymaleic acid: - US TSCA, Canadian DSL, EU EINECS, Australian AICS, Korean, Philippine PICCS and Chinese Xi irritant R 36/38 Irritant to eyes & skin R 41 Risk of serious damage to eyes S24/25 Avoid contact with skin and eyes S26/28 In case of contact eyes & skin, rinse with plenty water and seek medical advice Section 312/313: Not listed. Not listed under California proposition 65. |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
| Safety, health and environmental regulations specific for the product in question | European Inventory of Existing Commercial Chemical Substances (EINECS) -Listed.EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory- Listed. China Catalog of Hazardous chemicals 2015 Not- Listed. New Zealand Inventory of Chemicals (NZIoC)Listed. PICCS -Listed. Vietnam National Chemical Inventory -Listed. IECSC Listed. Korea Existing Chemicals List (KECL) -Listed. |
| Authorisations and/or restrictions on use | REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). : 2-Methylimidazole REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII) : 2-Methylimidazole |
| Other regulations | Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. |
| Chemical Safety Assessment | For this product a chemical safety assessment was not carried out. |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable. |
Availability
2-Methylimidazole manufacturer supplier distributor in Mumbai, Kandla, Kolkata, Vizag, Chennai, India, Fujairah, Dubai, Sharjah, UAE, Gulf, Middle East, Muscat Oman, Kenya Africa. Get the best quality of 2-Methylimidazole at a competitive price from us. We have ready stock of 2-Methylimidazole in India, UAE Gulf, Oman, Kenya Africa. Contact us for bulk as well as small orders.
