BENZANILIDE FOR SYNTHESIS
Benzanilide (N-phenylbenzamide, C13H11NO) is a white crystalline amide formed from benzoic acid (or benzoyl chloride) and aniline — the textbook benzoylation reaction in which a benzoyl group replaces the active hydrogen on an amine. Melting point 161–163 °C, density 1.315 g/cm³, insoluble in water, soluble in hot ethanol. RXSOL supplies the synthesis grade to dye, pigment and perfume manufacturers and to research and teaching laboratories, where it is also a substrate for palladium-catalysed diarylation to N-(2,6-diarylbenzoyl)anilines.
- Part number
- RXSOL-60-6604-038
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
Benzanilide is the organic compound with the formula C6H5C(O)NHC6H5. It is a white solid. Commercially available, it may be prepared by treating benzoic acid with aniline.
Benzanilide synthesis through amide bond formation was effectively carried out by palladium-doped clay catalyst using microwave irradiation under solvent-free conditions. Products were obtained with excellent yield in very short reaction time and only a small amount of the catalyst was used.
Technical specifications
Information on basic physical and chemical properties
| Odour threshold | No data available |
|---|---|
| pH | No data available |
| Relative evaporation rate (butylacetate=1) | No data available |
| Melting point | 161 - 163 °C |
| Freezing point | No data available |
| Boiling point | 117 °C |
| Flash point | No data available |
| Auto-ignition temperature | No data available |
| Decomposition temperature | No data available |
| Flammability (solid, gas) | No data available |
| Vapour pressure | No data available |
| Relative vapour density at 20 °C | No data available |
| Relative density | No data available |
| Density | 1.315 g/cm³ |
| Solubility | Water: Insoluble in water |
| Log Pow | No data available |
| Viscosity, kinematic | No data available |
| Viscosity, dynamic | No data available |
| Explosive properties | No data available |
| Oxidising properties | No data available |
| Explosive limits | No data available |
Applications
Benzanilide undergoes diarylation with aryl triflates or bromides in the presence of a palladium-based catalyst system to form corresponding N-(2,6-diarylbenzoyl)anilines. It is used in manufacture of dyes and perfumes.
Dosage and directions
Insertion of benzoyl moiety instead of an active hydrogen atom present in hydroxyl (OH) primary amino (NH2) or secondary amino group (NH) is usually termed as benzoylation reaction.
Characteristics and notes
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | RXSOL-60-6604-038 |
| Product Type | BENZANILIDE FOR SYNTHESIS |
| Revised date |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Stock Point : Mumbai, Kandla, Chennai, Visakhapatnam, Kolkata, Fujairah, Muscat Barka
| Phone | +91 22 27815541 / 42 |
| Fax | +91 22 2781 1318 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
3.1. Substances : BENZANILIDE FOR SYNTHESIS
CAS-No. : 93-98-1
Substance.
Contains no other components or impurities which will influence the classification of the
product.
2.1. Classification of the substance or mixture
Classification according to Regulation (EC) No. 1272/2008 [CLP]
Not classified
Classification according to Directive 67/548/EEC [DSD] or 1999/45/EC [DPD]
Not classified
Adverse physicochemical, human health and environmental effects
No additional information available
2.2. Label elements
Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to
display Extra classification(s) to display
No labelling applicable
2.3. Other hazards
No additional information available
4.1. Description of first aid measures
First-aid measures after inhalation : Remove person to fresh air and keep comfortable for breathing.
First-aid measures after skin contact : Wash with plenty of water/….
First-aid measures after eye contact : Rinse immediately with plenty of water.
First-aid measures after ingestion : Rinse mouth.
4.2. Most important symptoms and effects, both acute and delayed
No additional information available
4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically.
5.1. Extinguishing media
Suitable extinguishing media : Carbon dioxide. Dry powder. Foam. Water spray.
Unsuitable extinguishing media : Do not use a heavy water stream.
5.2. Special hazards arising from the substance or mixture
No additional information available
5.3. Advice for firefighters
Protection during firefighting : Do not enter fire area without proper protective
equipment, including respiratory protection.
6.1. Personal precautions, protective equipment and emergency procedures
6.1.1. For non-emergency personnel
Emergency procedures : Evacuate unnecessary personnel.
6.1.2. For emergency responders
Protective equipment : Equip cleanup crew with proper protection.
6.2. Environmental precautions
Avoid release to the environment.
6.3. Methods and material for containment and cleaning up
Methods for cleaning up : Soak up spills with inert solids, such as clay or diatomaceous earth as soon as possible.
On land, sweep or shovel into suitable containers.
6.4. Reference to other sections
No additional information available
7.1. Precautions for safe handling
Precautions for safe handling : Avoid contact with skin and eyes. Do not breathe vapours.
Avoid dust formation.
Hygiene measures : Wash hands and other exposed areas with mild soap and water before
eating, drinking or smoking and when leaving work.
7.2. Conditions for safe storage, including any incompatibilities
Storage conditions : Store in a well-ventilated place. Keep container tightly closed.
Store in a dry place. Protect from moisture.
7.3. Specific end use(s)
No additional information available
8.1. Control parameters
No additional information available
8.2. Exposure controls
Hand protection : Protective gloves
Eye protection : Chemical goggles or safety glasses
Skin and body protection : Wear suitable protective clothing
Respiratory protection : [In case of inadequate ventilation] wear respiratory protection.
9.1. Information on basic physical and chemical properties
Odour threshold : No data available
pH : No data available
Relative evaporation rate (butylacetate=1) : No data available
Melting point : 161 - 163 °C
Freezing point : No data available
Boiling point : 117 °C
Flash point : No data available
Auto-ignition temperature : No data available
Decomposition temperature : No data available
Flammability (solid, gas) : No data available
Vapour pressure : No data available
Relative vapour density at 20 °C : No data available
Relative density : No data available
Density : 1.315 g/cm³
Solubility : Water: Insoluble in water
Log Pow : No data available
Viscosity, kinematic : No data available
Viscosity, dynamic : No data available
Explosive properties : No data available
Oxidising properties : No data available
Explosive limits : No data available
9.2. Other information
No additional information available
10.1. Reactivity
No additional information available
10.2. Chemical stability
Stable under normal conditions.
10.3. Possibility of hazardous reactions
No additional information available
10.4. Conditions to avoid
Direct sunlight. Air contact. Moisture.
10.5. Incompatible materials
No additional information available
10.6. Hazardous decomposition products
No additional information available
11.1. Information on toxicological effects
Acute toxicity : Not classified
Skin corrosion/irritation : Not classified
Serious eye damage/irritation : Not classified
Respiratory or skin sensitisation : Not classified
Germ cell mutagenicity : Not classified
Carcinogenicity : Not classified
Reproductive toxicity : Not classified
STOT-single exposure : Not classified
STOT-repeated exposure : Not classified
Aspiration hazard : Not classified
12.1. Toxicity
No additional information available
12.2. Persistence and degradability
No additional information available
12.3. Bioaccumulative potential
No additional information available
12.4. Mobility in soil
No additional information available
12.5. Results of PBT and vPvB assessment
No additional information available
12.6. Other adverse effects
No additional information available
13.1. Waste treatment methods
No additional information available
In accordance with ADR / RID / IMDG / IATA / ADN
14.1. UN number
UN-No. (ADR) : Not applicable
UN-No. (IMDG) : Not applicable
UN-No. (IATA) : Not applicable
UN-No. (ADN) : Not applicable
UN-No. (RID) : Not applicable
14.2. UN proper shipping name
Proper Shipping Name (ADR) : Not applicable
Proper Shipping Name (IMDG) : Not applicable
Proper Shipping Name (IATA) : Not applicable
Proper Shipping Name (ADN) : Not applicable
Proper Shipping Name (RID) : Not applicable
14.3. Transport hazard class(es)
ADR : Transport hazard class(es) (ADR) : Not applicable
IMDG : Transport hazard class(es) (IMDG) : Not applicable
IATA : Transport hazard class(es) (IATA) : Not applicable
ADN : Transport hazard class(es) (ADN) : Not applicable
RID : Transport hazard class(es) (RID) : Not applicable
14.4. Packing group
Packing group (ADR) : Not applicable
Packing group (IMDG) : Not applicable
Packing group (IATA) : Not applicable
Packing group (ADN) : Not applicable
Packing group (RID) : Not applicable
14.5. Environmental hazards
Dangerous for the environment : No
Marine pollutant : No
Other information : No supplementary information available
14.6. Special precautions for user
Overland transport-
No data available
Transport by sea -
No data available
Air transport -
No data available
Inland waterway transport -
No data available
Rail transport -
No data available
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable
ADR - Packing instructions : P001
ADR - Limited Quantity : 1 L
ADR - Tunnel code : D/E : Bulk or tank carriage: Passage forbidden through tunnels of
category D and
E. Other carriage: Passage forbidden through tunnels of category E.
14.2. Sea transport (IMDG) [English only]
Proper shipping name : ACETIC ACID,
UN N° : 2789
IMO-IMDG - Class or division : 8 : Corrosive substance. ( 3 : Flammable liquid. )
IMO-IMDG - Packing group : II
IMO- IMDG - Packing instructions : P001
IMO-IMDG - Limited quantities : 1 L
IMO-IMDG - Marine pollution : No
EMS-Nr : F-E S-C
14.3. Air transport (ICAO-IATA) [English only]
Proper shipping name : ACETIC ACID
UN N° : 2789
IATA - Class or division : 8 : Corrosive substance. ( 3 : Flammable liquid. )
IATA - Packing group : II
IATA - Passenger and Cargo Aircraft : ALLOWED
- Passenger and Cargo - Packing : 851
instruction
- Passenger and Cargo - Maximum : 1 L
Quantity/Packing
IATA - Cargo only : ALLOWED
- Cargo only - Packing instruction : 855
- Cargo only - Maximum Quantity/ : 30 L
Packing
IATA - Limited Quantites : 0.5 L
ERG-Nr : 8F
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
15.1.1. EU-Regulations
No REACH Annex XVII restrictions BENZANILIDE FOR SYNTHESIS is not on the REACH Candidate List
BENZANILIDE FOR SYNTHESIS is not on the REACH Annex XIV List
15.1.2. National regulations
Germany
12th Ordinance Implementing the Federal
Immission Control Act - 12.BImSchV : Is not subject of the 12. BlmSchV (Hazardous Incident Ordinance)
Netherlands
SZW-lijst van kankerverwekkende stoffen : The substance is not listed
SZW-lijst van mutagene stoffen : The substance is not listed
NIET-limitatieve lijst van voor de voortplanting giftige stoffen – Borstvoeding : The substance is not listed
NIET-limitatieve lijst van voor de voortplanting giftige stoffen – Vruchtbaarheid : The substance is not listed
NIET-limitatieve lijst van voor de voortplanting giftige stoffen – Ontwikkeling : The substance is not listed
15.2. Chemical safety assessment
No additional information available
Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic.
vPvB: very persistent and very bioaccumulative
Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN
PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification,
labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Further information : None.
In accordance with REACH Regulation (CE) Nº 1907/2006 and with CLP Regulation
(CE) Nº 1272/2008
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
Availability
[BENZANILIDE FOR SYNTHESIS] manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman. Lab
chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada.
[BENZANILIDE FOR SYNTHESIS] is available in small packing as well as in bulk. Buy premium quality [BENZANILIDE FOR SYNTHESIS] and other lab chemicals from one of the most trusted brands.
Frequently asked questions
What is the formula of benzanilide?
C6H5C(O)NHC6H5 (C13H11NO), molecular weight 197.24.
How is benzanilide synthesised?
Classically by heating benzoic acid with aniline (or benzoyl chloride with aniline under Schotten–Baumann conditions); solvent-free microwave methods over Pd-doped clay give high yield in minutes. Grind the product finely before extracting unreacted aniline and benzoic acid.
Uses?
Dye and perfume intermediate, model substrate in amide-bond and C–H activation chemistry.
