COUMARIN FOR SYNTHESIS
- Part number
- RXSOL-60-6604-359
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
coumarins could be synthesized with many different methods like Perkin reaction, Knoevenagel condensation,
Pechmann condensation, Wittig reaction, Baylis-Hillman reaction,
Claisen rearrangement and Vilsmeier-Haack and Suzuki cross-coupling reaction
Applications
Coumarins are commonly used in the treatment of prostate cancer, renal cell carcinoma and leukemia, and they also have the ability to counteract the side effects caused by radiotherapy. Both natural and synthetic coumarin derivatives draw attention due to their photochemotherapy and therapeutic applications in cancer.
Dosage and directions
coumarin was well tolerated at the applied doses (600–5000 mgs)
Characteristics and notes
Coumarin is prepared by treating the sodium salt of ortho-hydroxybenzqaldehyde with acetic anhydride. It involves other methods which have been developed by Pechmann Claisen, Knoevenagal, Reformatsky reaction and Wittig for the synthesis of pyrone-ring moieties in coumarins.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name |
|
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| Product Type | COUMARIN FOR SYNTHESIS |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Stock Point : Mumbai, Kandla, Chennai, Visakhapatnam, Kolkata, Fujairah, Muscat Barka
| Phone | +91 22 27815541 / 42 |
| Fax | +91 22 2781 1318 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
2.1. Substances : COUMARIN For synthesis
CAS-No.: 91-64-5
Substance.
Contains no other components or impurities which will influence the classification of the
product.
3.1 Classification of the substance or mixture
Classification according to Regulation (EC) No. 1272/2008 [CLP]
Acute toxicity (oral), H301
Category 3
Full text of H statements : see section 16
Classification according to Directive 67/548/EEC [DSD] or 1999/45/EC [DPD]
Not classified
Adverse physicochemical, human health and environmental effects
No additional information available
3.2. Label elements
Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to
displayExtra classification(s) to display
Symbol(s) :
R Phrase(s) : R22: Harmful if swallowed.
Hazard pictograms
Signal word : Danger
Hazard statements: H301 - Toxic if swallowed.
Precautionary statements : P301+P310 - IF SWALLOWED: Immediately call a
POISON CENTER/doctor
3.3. Other hazards
No additional information available
4.1. Description of first aid measures
First-aid measures after inhalation : Remove person to fresh air and keep comfortable for
breathing.
First-aid measures after skin contact : Wash skin with plenty of water.
First-aid measures after eye contact : Remove contact lenses, if present and easy to do
. Continue rinsing. Rinse cautiously with water for several minutes. If eye irritation
persists: Get medical advice/attention
First-aid measures after ingestion : Rinse mouth out with water.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms/effects after ingestion : Toxic if swallowed
. 4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically
5.1. Extinguishing media
Suitable extinguishing media : dry chemical powder, alcohol-resistant foam, carbon
dioxide (CO2)
. Unsuitable extinguishing media : Do not use a heavy water stream.
5.2. Special hazards arising from the substance or mixture
No additional information available
5.3. Advice for firefighters
Protection during firefighting : Do not attempt to take action without suitable protective
equipment.
6.1. Personal precautions, protective equipment and emergency procedures
6.1.1. For non-emergency personnel Emergency
procedures: Avoid contact with skin, eyes and clothing.
6.1.2. For emergency responders
Protective equipment : Use personal protective equipmentas required.
6.2. Environmental precautions
Avoid release to the environment.
6.3. Methods and material for containment and cleaning up
Methods for cleaning up : Clean contaminated surfaces with an excess of water.
6.4. Reference to other sections
No additional information available.
7.1. Precautions for safe handling
Precautions for safe handling : Avoid contact with skin and eyes
Hygiene measures : Wash hands and other exposed areas with mild soap and water before
eating, drinking or smoking and when leaving work.
7.2. Conditions for safe storage, including any incompatibilities
Storage conditions : Store in a well-ventilated place. Keep container tightly closed.
7.3. Specific end use(s)
No additional information available
8.1. Control parameters
No additional information available
8.2. Exposure controls Hand protection : Protective gloves
Eye protection : Chemical goggles or safety glasses
Skin and body protection : Wear suitable protective clothing
Respiratory protection : Wear respiratory protection
9.1. Information on basic physical and chemical properties
Odour threshold : No data available
pH : No data available
Relative evaporation rate (butylacetate=1) : No data available
Melting point : 68 - 73 °C Freezing point : No data available
Boiling point : 298 °C Flash point : No data available
Auto-ignition temperature : No data available
Decomposition temperature : No data available
Flammability (solid, gas) : No data available
Vapour pressure : No data available
Relative vapour density at 20 °C : No data available
Relative density : No data available
Solubility : No data available
Log Pow : No data available
Viscosity, kinematic : No data available
Viscosity, dynamic : No data available
Explosive properties : No data available
Oxidising properties : No data available
Explosive limits : No data available
9.2. Other information
No additional information available
10.1. Reactivity
No additional information available
10.2. Chemical stability
Stable under normal conditions.
10.3. Possibility of hazardous reactions
No additional information available
10.4. Conditions to avoid Air contact. Direct sunlight
. Moisture. 10.5. Incompatible materials
No additional information available
10.6. Hazardous decomposition products
No additional information available
Acute toxicity : Oral: Toxic if swallowed.
Skin corrosion/irritation : Not classified
Serious eye damage/irritation : Not classified
Respiratory or skin sensitisation : Not classified
Germ cell mutagenicity : Not classified
Carcinogenicity : Not classified
Reproductive toxicity : Not classified
STOT-single exposure : Not classified
STOT-repeated exposure : Not classified
Aspiration hazard : Not classified
12.1. Toxicity
No additional information available
12.2. Persistence and degradability
No additional information available
12.3. Bioaccumulative potential
No additional information available
12.4. Mobility in soil
No additional information available
12.5. Results of PBT and vPvB assessment
No additional information available
12.6. Other adverse effects
No additional information available
13.1. Waste treatment methods
No additional information available
In accordance with ADR / RID / IMDG / IATA / ADN
14.1. UN number
UN-No. (ADR) : 2811
UN-No. (IMDG) : 2811
UN-No. (IATA) : 2811
UN-No. (ADN) : 2811
UN-No. (RID) : 2811
14.2. UN proper shipping name
Proper Shipping Name (ADR) : TOXIC SOLID, ORGANIC, N.O.S
. Proper Shipping Name (IMDG) : TOXIC SOLID, ORGANIC, N.O.S.
Proper Shipping Name (IATA) : Toxic solid, organic, n.o.s.
Proper Shipping Name (ADN) : TOXIC SOLID, ORGANIC, N.O.S.
Proper Shipping Name (RID) : TOXIC SOLID, ORGANIC, N.O.S.
Transport document description (ADR) : UN 2811 TOXIC SOLID, ORGANIC, N.O.S.,
6.1, III, (E)
Transport document description (IMDG) : UN 2811 TOXIC SOLID, ORGANIC, N.O.S.,
6.1, III
Transport document description (IATA) : UN 2811 Toxic solid, organic, n.o.s.,
6.1, III
Transport document description (ADN) : UN 2811 TOXIC SOLID, ORGANIC, N.O.S.,
6.1, III
Transport document description (RID) : UN 2811 TOXIC SOLID, ORGANIC, N.O.S.,
6.1, III
14.3. Transport hazard class(es)
ADR- Transport hazard class(es) (ADR) : 6.1
Danger labels (ADR) : 6.1
IMDG- Transport hazard class(es) (IMDG) : 6.1
IATA- Transport hazard class(es) (IATA) : 6.1
Hazard labels (IATA) : 6.1
ADN- Transport hazard class(es) (ADN) : 6.1
Danger labels (ADN) : 6.1
RID- Transport hazard class(es) (RID) : 6.1
Danger labels (RID) : 6.1
14.4. Packing group Packing group (ADR) : III
Packing group (IMDG) : III
Packing group (IATA) : III
Packing group (ADN) : III
Packing group (RID) : III
14.5. Environmental hazards
Dangerous for the environment : No
Marine pollutant : No
Other information : No supplementary information available
14.6. Special precautions for user
Overland transport- Classification code (ADR) : T2
Special provisions (ADR) : 274, 614
Limited quantities (ADR) : 5kg
Excepted quantities (ADR) : E1
Packing instructions (ADR) : P002, IBC08, LP02, R001
Special packing provisions (ADR) : B3
Mixed packing provisions (ADR) : MP10
Portable tank and bulk container instructions (ADR) : T1
Portable tank and bulk container special provisions (ADR) : TP33
Tank code (ADR) : SGAH, L4BH
Tank special provisions (ADR) : TU15, TE19
Vehicle for tank carriage : AT
Transport category (ADR) : 2
Special provisions for carriage – Bulk (ADR) : VC1, VC2, AP7
Special provisions for carriage - Loading, unloading and handling (ADR) : CV13, CV28
Special provisions for carriage – Operation (ADR) : S9
Hazard identification number (Kemler No.) : 60
Orange plates :
Tunnel restriction code (ADR) : E
EAC code : 2X
Transport by sea- Special provisions (IMDG) : 223, 274
Packing instructions (IMDG) : P002
IBC packing instructions (IMDG) : IBC08
IBC special provisions (IMDG) : B3
Tank instructions (IMDG) : T1
Tank special provisions (IMDG) : TP33
EmS-No. (Fire) : F-A
EmS-No. (Spillage) : S-A
Stowage category (IMDG) : A
Properties and observations (IMDG :Toxic if swallowed, by skin contact or by
inhalation.
Air transport -PCA Excepted quantities (IATA) : E1
PCA Limited quantities (IATA) : Y645
PCA limited quantity max net quantity (IATA) : 10kg
PCA packing instructions (IATA) : 670
PCA max net quantity (IATA) : 100kg
CAO packing instructions (IATA) : 677
CAO max net quantity (IATA) : 200kg
Special provisions (IATA) : A3, A5
ERG code (IATA) : 6L
Inland waterway transport- Classification code (ADN) : T2
Special provisions (ADN) : 274, 614, 802
Limited quantities (ADN) : 5 kg
Excepted quantities (ADN) : E1
Carriage permitted (ADN) : T
Equipment required (ADN) : PP, EP
Number of blue cones/lights (ADN) : 0
Rail transport- Classification code (RID) : T2
Special provisions (RID) : 274, 614
Excepted quantities (RID) : E1
Packing instructions (RID) : P002, IBC08, LP02, R001
Special packing provisions (RID) : B3
Mixed packing provisions (RID) : MP10
Portable tank and bulk container instructions (RID) : T1
Portable tank and bulk container special provisions (RID) : TP33
Tank codes for RID tanks (RID) : SGAH, L4BH
Special provisions for RID tanks (RID) : TU15
Transport category (RID) : 2
Special provisions for carriage – Bulk (RID) : VC1, VC2, AP7
Special provisions for carriage - Loading, unloading and handling (RID) : CW13, CW28
, CW31
Colis express (express parcels) (RID) : CE11
Hazard identification number (RID) : 60
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable
15.1. Safety, health and environmental regulations/legislation specific for the
substance or mixture
15.1.1. EU-Regulations
No REACH Annex XVII restrictions
COUMARIN For synthesis is not on the REACH Candidate List
COUMARIN For synthesis is not on the REACH Annex XIV List
15.1.2. National regulations
Germany
Reference to AwSV : Water hazard class (WGK) 1, Slightly hazardous to water
(Classification according to AwSV; ID No. 3522)
12th Ordinance Implementing the Federal
Immission Control Act - 12.BImSchV : Is not subject of the 12. BlmSchV (Hazardous
Incident Ordinance)
Netherlands
SZW-lijst van kankerverwekkende stoffen : The substance is not listed
SZW-lijst van mutagene stoffen : The substance is not listed
NIET-limitatieve lijst van voor de
voortplanting giftige stoffen – Borstvoeding : The substance is not listed
NIET-limitatieve lijst van voor de
voortplanting giftige stoffen –
Vruchtbaarheid : The substance is not listed
NIET-limitatieve lijst van voor
de voortplanting giftige stoffen – Ontwikkeling : The substance is not listed
Denmark
Recommendations Danish Regulation : Young people below the age of 18 years are not
allowed to use the product
15.2. Chemical safety assessment
No additional information available
Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic.
vPvB: very persistent and very bioaccumulative
Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN
PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification,
labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Further information : None.
In accordance with REACH Regulation (CE) Nº 1907/2006 and with CLP Regulation
(CE) Nº 1272/2008
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
Availability
[PRODUCT NAME] manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman.
Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada.
[PRODUCT NAME] is available in small packing as well as in bulk. Buy premium quality [PRODUCT NAME] and other lab chemicals from one of the most trusted brands.
COUMARIN FOR SYNTHESIS manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman.
Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada.
COUMARIN FOR SYNTHESIS is available in small packing as well as in bulk. Buy premium quality COUMARIN FOR SYNTHESIS and other lab chemicals from one of the most trusted brands.
