Overview
Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea.
Its aglycone is digitogenin, a spirostan steroid.
Applications
Digitonin is used as the cell-permeabilizing agent as it is a weak nonionic detergent, which at low concentrations selectively renders the plasma membrane permeable, causing it to release cytosolic components but to leave other organelles intact.
Dosage and directions
Digitonin functions as a nonionic detergent with an uncharged hydrophilic head group and is often used to break down chemical interactions involving proteins and lipids
Characteristics and notes
Bioinformatic analysis predict that it is a membrane protein so our hypothesis is that it may be a mitochondria (probably inner) membrane protein.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name |
|
|
| Product Type | DIGITONIN AR | |
| Revised date |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Stock Point : Mumbai, Kandla, Chennai, Visakhapatnam, Kolkata, Fujairah, Muscat Barka
| Phone | +91 22 27815541 / 42 |
| Fax | +91 22 2781 1318 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
2.1. Substances: DIGITONIN AR
CAS-No. : 11024-24-1
Substance.
Contains no other components or impurities which will influence the classification of the
product
3.1. Classification of the substance or
mixture Classification according to Regulation (EC) No. 1272/2008 [CLP]
Acute toxicity (oral), H301
Category 3
Acute toxicity (dermal), H311
Category 3
Acute toxicity (inhal.), H330
Category
2 Classification according to Directive 67/548/EEC [DSD] or 1999/45/EC [DPD]
Adverse physicochemical, human health and environmental effects
No additional information available
3.2. Label elements
Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to
displayExtra classification(s) to display
Symbol(s) : T : Very toxic
R Phrase(s) : R25: Toxic if swallowed.
R33: Danger of cumulative effects
S Phrase(s) : S22: Do not breath dust.
S37: Wear suitable gloves
. S45: In case of accident or if you feel unwell, seek medical advice immediately (show the
label where possible)
. Hazard pictograms
Signal word: Danger
Hazard statements: H301+H311 - Toxic if swallowed or in contact with skin
H330 - Fatal if inhaled.
Precautionary statements: P260 - Do not breathe vapours, spray, dust, fume, gas.
P280 - Wear protective gloves, protective clothing, eye protection, face protection.
P284 - Wear respiratory protection
. P310 - Immediately call a POISON CENTER/doctor
3.3. Other hazards
No additional information available.
4.1. Description of first aid measures
First-aid measures after inhalation : Assure fresh air breathing. If breathing is difficult
, remove victim to fresh air and keep at rest in a position comfortable for breathing. Get
medical advice/attention
. First-aid measures after skin contact : Immediately call a POISON CENTER/doctor.
Take off immediately all contaminated clothing. Wash with plenty of water/….
First-aid measures after eye contact : Rinse cautiously with water for several minutes
. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical
advice/attention.
First-aid measures after ingestion : Rinse mouth. Obtain emergency medical attention.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms/effects after inhalation : Fatal if inhaled.
Symptoms/effects after skin contact : Toxic in contact with skin.
Symptoms/effects after ingestion : Toxic if swallowed.
4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically
.
5.1. Extinguishing media
Suitable extinguishing media : Carbon dioxide. Dry powder. Foam. Water spray.
Unsuitable extinguishing media : Do not use a heavy water stream
. 5.2. Special hazards arising from the substance or mixture
No additional information available
5.3. Advice for firefighters
Protection during firefighting : Do not enter fire area without proper protective
equipment, including respiratory protection.
6.1. Personal precautions, protective equipment and emergency procedures
6.1.1. For non-emergency personnel
Emergency procedures : Evacuate unnecessary personnel.
6.1.2. For emergency responder
Protective equipment : Equip cleanup crew with proper protection.
Emergency procedures : Ventilate area
. 6.2. Environmental precautions
Avoid release to the environment
6.3. Methods and material for containment and cleaning up
Methods for cleaning up : Soak up spills with inert solids, such as clay or diatomaceous
earth as soon as possible. On land, sweep or shovel into suitable containers.
6.4. Reference to other sections
No additional information available
7.1. Precautions for safe handling
Precautions for safe handling : Avoid contact with skin and eyes. Do not breathe vapours.
Provide good ventilation in process area to prevent formation of vapour.
Hygiene measures : Do not eat, drink or smoke when using this product. Wash hands and
other exposed areas with mild soap and water before eating, drinking or smoking and
when leaving work.
7.2. Conditions for safe storage, including any incompatibilities
Storage conditions : Store in a well-ventilated place. Keep container tightly closed
. 7.3. Specific end use(s)
No additional information available
8.1. Control parameters
No additional information available
8.2. Exposure controls Hand protection : Protective gloves
Eye protection : Chemical goggles or safety glasses
Skin and body protection : Wear suitable protective clothing
Respiratory protection : [In case of inadequate ventilation] wear respiratory protection.
9.1. Information on basic physical and chemical properties
Odour threshold : No data available
pH : No data available
Relative evaporation rate (butylacetate=1) : No data available
Melting point : 230 - 240 °C
Freezing point : No data available
Boiling point : No data available
Flash point : No data available
Auto-ignition temperature : No data available
Decomposition temperature : 2400 °C
Flammability (solid, gas) : No data available
Vapour pressure : No data available
Relative vapour density at 20 °C : No data available
Relative density : No data available
Solubility : Water: Insoluble
Log Pow : No data available
Viscosity, kinematic : No data available
Viscosity, dynamic : No data available
Explosive properties : No data available
Oxidising properties : No data available
Explosive limits : No data available
9.2. Other information
No additional information available
10.1. Reactivity No additional information available
10.2. Chemical stability
Stable under normal conditions.
10.3. Possibility of hazardous reactions
No additional information available
10.4. Conditions to avoid
Air contact. Direct sunlight. Moisture.
10.5. Incompatible materials
No additional information available
10.6. Hazardous decomposition products
No additional information available
11.1. Information on toxicological effects
Acute toxicity : Oral: Toxic if swallowed. Dermal: Toxic in contact with skin. Inhalation
: Fatal if inhaled
Skin corrosion/irritation : Not classified
Serious eye damage/irritation : Not classified
Respiratory or skin sensitisation : Not classified
Germ cell mutagenicity : Not classified
Carcinogenicity : Not classified
Reproductive toxicity : Not classified
STOT-single exposure : Not classified
STOT-repeated exposure : Not classified
Aspiration hazard : Not classified
Potential adverse human health effects
and symptoms : Toxic if swallowed. Toxic in contact with skin.
12.1. Toxicity
No additional information available
12.2. Persistence and degradability
additional information available
12.3. Bioaccumulative potential
No additional information available
12.4. Mobility in soil
No additional information available
12.5. Results of PBT and vPvB assessment
No additional information available
12.6. Other adverse effects
No additional information available
13.1. Waste treatment methods
Product/Packaging disposal
Recommendations : Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national and/or international
regulation
. Ecology - waste materials : Hazardous waste due to toxicity
In accordance with ADR / RID / IMDG / IATA / ADN
14.1. UN number
UN-No. (ADR) : 3462
UN-No. (IMDG) : 3462
UN-No. (IATA) : 3462
UN-No. (ADN) : 3462
UN-No. (RID) : 3462
14.2. UN proper shipping name
Proper Shipping Name (ADR) : TOXINS, EXTRACTED FROM LIVING SOURCES
, SOLID, N.O.S.
Proper Shipping Name (IMDG) : TOXINS, EXTRACTED FROM LIVING SOURCES,
SOLID, N.O.S.
Proper Shipping Name (IATA) : Toxins, extracted from living sources, solid, n.o.s.
Proper Shipping Name (ADN) : TOXINS, EXTRACTED FROM LIVING SOURCES,
SOLID, N.O.S
. Proper Shipping Name (RID) : TOXINS, EXTRACTED FROM LIVING SOURCES,
SOLID, N.O.S.
Transport document description (ADR) : UN 3462 TOXINS, EXTRACTED FROM
LIVING SOURCES, SOLID, N.O.S., 6.1, III,
(E)
Transport document description (IMDG) : UN 3462 TOXINS, EXTRACTED FROM
LIVING SOURCES, SOLID, N.O.S., 6.1, II
Transport document description (IATA) : UN 3462 Toxins, extracted from living sources, solid, n.o.s.
, 6.1, III Transport document description (ADN) : UN 3462 TOXINS, EXTRACTED FROM
LIVING SOURCES, SOLID, N.O.S., 6.1, III
Transport document description (RID) : UN 3462 TOXINS, EXTRACTED FROM
LIVING SOURCES, SOLID, N.O.S., 6.1, III
14.3. Transport hazard class(es
ADR- Transport hazard class(es) (ADR) : 6.1
Danger labels (ADR) : 6.1
IMDG- Transport hazard class(es) (IMDG) : 6.1
Danger labels (IMDG) : 6.1
IATA- Transport hazard class(es) (IATA) : 6.1
Hazard labels (IATA) : 6.1
ADN- Transport hazard class(es) (ADN) : 6.1
Danger labels (ADN) : 6.1
RID- Transport hazard class(es) (RID) : 6.1
Danger labels (RID) : 6.1
14.4. Packing group
Packing group (ADR) : III
Packing group (IMDG) : III
Packing group (IATA) : III
Packing group (ADN) : III
Packing group (RID) : III
14.5. Environmental hazards
Dangerous for the environment : No
Marine pollutant : No
Other information : No supplementary information available
14.6. Special precautions for user
Overland transport- Classification code (ADR) : T2
Special provisions (ADR) : 210, 274
Limited quantities (ADR) : 5kg
Excepted quantities (ADR) : E1
Packing instructions (ADR) : P002, IBC08, R001
Special packing provisions (ADR) : B3
Mixed packing provisions (ADR) : MP10
Portable tank and bulk container instructions (ADR) : T1
Portable tank and bulk container special provisions (ADR) : TP33
Tank code (ADR) : SGAH, L4BH
Tank special provisions (ADR) : TU15, TE19
Vehicle for tank carriage : AT Transport category (ADR) : 2
Special provisions for carriage – Bulk (ADR) : VC1, VC2, AP7
Special provisions for carriage - Loading, unloading and handling (ADR) : CV13, CV28
Special provisions for carriage – Operation (ADR) : S9
Hazard identification number (Kemler No.) : 60
Orange plates
: Tunnel restriction code (ADR) : E
EAC code : 2X
Transport by sea- Special provisions (IMDG) : 210, 223, 274
Packing instructions (IMDG) : P002
IBC packing instructions (IMDG) : IBC08
IBC special provisions (IMDG) : B3
Tank instructions (IMDG) : T1
Tank special provisions (IMDG) : TP33
EmS-No. (Fire) : F-A
EmS-No. (Spillage) : S-A
Stowage category (IMDG) : A
Properties and observations (IMDG) : Toxins from plant, animal or bacterial sources
which contain infectious substances or toxins that are contained in infectious substances
should be classified in class 6.2
. Toxic if swallowed, by skin contact or by inhalation
. MFAG-No : 153
Air transport- PCA Excepted quantities (IATA) : E1
PCA Limited quantities (IATA) : Y645
PCA limited quantity max net quantity (IATA) : 10kg
PCA packing instructions (IATA) : 670
PCA max net quantity (IATA) : 100kg
packing instructions (IATA) : 677
CAO max net quantity (IATA) : 200kg
Special provisions (IATA) : A3, A43
ERG code (IATA) : 6L
Inland waterway transport- Classification code (ADN) : T2
Special provisions (ADN) : 210, 274, 802
Limited quantities (ADN) : 5 kg
Excepted quantities (ADN) : E1
Equipment required (ADN) : PP, EP
Number of blue cones/lights (ADN) : 0
Rail transport- Classification code (RID) : T2
Special provisions (RID) : 210, 274
Excepted quantities (RID) : E1
Packing instructions (RID) : P002, IBC08, R001
Special packing provisions (RID) : B3
Mixed packing provisions (RID) : MP10
Portable tank and bulk container instructions (RID) : T1
Portable tank and bulk container special provisions (RID) : TP33
Tank codes for RID tanks (RID) : SGAH, L4BH
Special provisions for RID tanks (RID) : TU15
Transport category (RID) : 2
Special provisions for carriage – Bulk (RID) : VC1, VC2, AP7
Special provisions for carriage - Loading, unloading and handling (RID): CW13, CW28
, CW31
Colis express (express parcels) (RID) : CE11
Hazard identification number (RID) : 60
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable
15.1. Safety, health and environmental regulations/legislation specific for the
substance or mixture
15.1.1. EU-Regulations
No REACH Annex XVII restrictions
DIGITONIN AR is not on the REACH Candidate List
DIGITONIN AR is not on the REACH Annex XIV List
15.1.2. National regulations
Germany
Reference to AwSV : Water hazard class (WGK) 3, severe hazard to water (Classification
according to AwSV; ID No. 1040)
12th Ordinance Implementing the Federal
Immission Control Act - 12.BImSchV: Is not subject of the 12. BlmSchV (Hazardous
Incident Ordinance)
Netherlands
SZW-lijst van kankerverwekkende stoffen : The substance is not listed
SZW-lijst van mutagene stoffen : The substance is not listed
NIET-limitatieve lijst van voor de
voortplanting giftige stoffen – Borstvoeding : The substance is not listed
NIET-limitatieve lijst van voor de
voortplanting giftige stoffen – Vruchtbaarheid : The substance is not listed
NIET-limitatieve lijst van voor de
voortplanting giftige stoffen – Ontwikkeling: The substance is not listed
Denmark
Recommendations Danish Regulation : Young people below the age of 18 years are not
allowed to use the product
Pregnant/breastfeeding women working with the product must not be in direct
contact with the product
15.2. Chemical safety assessment
No additional information available
Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic.
vPvB: very persistent and very bioaccumulative
Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN
PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification
labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Further information : None. In accordance with REACH Regulation (CE) Nº 1907/2006 and with CLP
Regulation (CE) Nº 1272/2008
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
Availability
DI GITONIN AR manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman.
Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada.
DI GITONIN AR is available in small packing as well as in bulk. Buy premium quality DI GITONIN AR and other lab chemicals from one of the most trusted brands.
