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Product Name |
DIOXANE 1,4 |
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Part Number |
RXSOL-19-1150-050 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
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Phone |
+91 22 20871200 - 1400 |
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Fax |
+91 22 27612100 :::AOH :0091 9821214367 |
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Email |
rxsolchemicals@gmail.com |
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Website |
www.rxmraine.com |
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Chemical Name |
CAS |
EC number |
Weight |
Formula |
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1,4-Dioxane |
123-91-1 |
204-661-8 |
<= 100 % |
C4H8O2 |
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Signal Word |
Danger |
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Hazard Statements |
H225 Highly flammable liquid and vapor. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H350 May cause cancer. |
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P280 Wear protective gloves.P305 + P351 + P338 |
Wear eye protection/ face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
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Precautionary statements |
P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. |
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Classification of the substance or mixture |
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008. |
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Supplemental Hazard Statements |
EUH019 May form explosive peroxides. EUH066 Repeated exposure may cause skin dryness or cracking. Restricted to professional users. |
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Other hazards |
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
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General advice |
Show this material safety data sheet to the doctor in attendance. |
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If inhaled |
After inhalation: fresh air. Call in physician. |
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Eye Contact |
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. |
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Swallowed |
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary failure possible after aspiration of vomit. Call a physician immediately. |
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Skin Contact |
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician. |
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Inhalation |
Remove patient to fresh air, keep warm and at rest and get medical assistance in necessary. |
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Ingestion |
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately. |
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Most important symptoms and effects, both acute and delaye |
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
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Indication of any immediate medical attention and special treatment needed |
No data available |
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Flammability |
May be combustible at high temperature. |
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Suitable extinguishing media |
Water Foam Carbon dioxide (CO2) Dry powder |
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Unsuitable extinguishing media |
For this substance/mixture no limitations of extinguishing agents are given. |
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Special hazards arising from the substance or mixture |
Carbon oxides Combustible. Pay attention to flashback. Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures. |
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Further information |
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system. |
Hazardous combustion
products |
Fire may cause the evolution of Sulphur oxides, nitrogen oxides. |
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Advice for firefighters |
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. |
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Protective Equipment |
Use personal protective equipment. |
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Specific Hazards Arising from the Chemical |
Has a fire-promoting effect due to the release of oxygen.
Ambient fire may liberate hazardous vapours. |
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Personal precautions, protective equipment and emergency procedures |
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. |
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Spillage |
Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal. |
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Personal Protection |
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: Protective equipment see section 8. |
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Enviromental Precaution |
Do not let product enter drains. Risk of explosion. |
Methods and materials for
containment and cleaning |
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area. |
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Advice on safe handling |
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. |
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Advice on protection against fire and explosion |
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. |
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Incompatible materials |
Keep away from alkalis, strong oxidizing agents and metals. Provide containment walls of adequate capacity to hold any accidental spills. |
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Hygiene measures |
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. |
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Conditions for safe storage, including any incompatibilities |
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. |
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Storage conditions |
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons. Test for peroxide formation periodically and before distillation. |
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Storage class |
Storage class (TRGS 510): 3: Flammable liquids |
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Specific end use(s) |
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
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Advice on general occupational hygiene |
Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance. |
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Requirements for storage |
Keep in cool and store under shade. |
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Application Area |
Routes of exposure |
Health effect |
Value |
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Workers |
Inhalation |
Long-term systemic effects |
144 mg/m3 |
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Workers |
Inhalation |
Long-term systemic effects |
73 mg/m3 |
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Workers |
Skin contact |
Long-term systemic effects |
21 mg/m3 |
Predicted No Effect Concentration (PNEC)
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Compartment |
Value |
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Soil |
0,153 mg/kg |
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Sea water |
0,67 mg/l |
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Fresh water |
10 mg/l |
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Sewage treatment plant |
2700 mg/l |
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Aquatic intermittent release |
10 mg/l |
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Exposure controls |
No specific additional engineering controls are required. Provide good natural or artificial ventilation. |
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Engineering Control |
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. |
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Eye/face protection |
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses |
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Body Protection |
Flame retardant antistatic protective clothing. |
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Skin protection |
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: butyl-rubber Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject® (KCL 898) This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Viton® Minimum layer thickness: 0,7 mm Break through time: 120 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) |
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Respiratory protection |
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. |
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Other Protection Measure |
Handle in accordance with good industrial hygiene and safety practice. |
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Control of environmental exposure |
Do not let product enter drains. Risk of explosion. |
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Physical state |
Liquid |
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Colour |
Colorless |
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Odour |
No data available |
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Odor Threshold |
Not Applicable |
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pH |
6,0 - 8 at 500 g/l at 20 °C |
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Melting Point |
10 - 12 °C - lit. |
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Boiling Point |
100 - 102 °C - lit. |
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Flash Point |
11 °C - closed cup |
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Evaporation Rate |
Not Applicable |
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Flammability (solid, gas) |
No data available |
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Explosive limits |
No Data Available |
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Upper/lower flammability or explosive limits |
22 %(V) / 2 %(V) |
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Autoignition temperature |
190,55 °C |
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Decomposition temperature |
No data available |
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Viscosity, kinematic / dynamic |
1,27 mm2/s at 20 °C / 1,2 mPa.s at 25 °C1,32 mPa.s at 20 °C |
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Vapour pressure |
36 hPa at 20 °C 53 hPa at 25,20 °C |
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Density |
1,034 g/cm3 at 25 °C - lit. |
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Relative Vapour Density |
3,04 - (Air = 1.0) |
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Relative Density |
1,03 at 20 °C |
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Freezing point |
No data available |
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Specific Gravity |
No data available |
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Partition coefficient |
log Pow: -0,42 |
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Explosive properties |
No data available |
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Solubility |
1.000 g/l at 20 °C |
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Ignition temperature |
No information available. |
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Particle characteristics |
No data available |
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Reactivity |
Formation of peroxides possible. Vapors may form explosive mixture with air. |
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Stability |
The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions. Contains the following stabilizer(s): butyl hydroxytoluene (BHT) (0,0025 %) |
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Possibility of hazardous reactions |
No data available |
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Conditions to avoid |
Warming. Moisture. |
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Incompatible materials |
No data available |
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Hazardous Polymerization |
In the event of fire: see section 5 |
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Acute toxicity |
LD50 Oral - Rat - male and female - 5.150 mg/kg (OECD Test Guideline 401) Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract, Lung edema LD50 Dermal - Rabbit - 7.378 mg/kg Remarks: (RTECS) |
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Skin corrosion/irritation |
Skin - Rabbit Result: No skin irritation - 20 h Remarks: (IUCLID) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) |
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Serious eye damage/eye irritation |
Eyes - Rabbit Result: Eye irritation (OECD Test Guideline 405) Remarks: (Regulation (EC) No 1272/2008, Annex VI) |
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Respiratory or skin sensitization |
Maximization Test - Guinea pig Result: negative (Regulation (EC) No. 440/2008, Annex, B.6) |
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Toxic Effects on Human |
May cause damage to the following organs: upper respiratory tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant, lung sensitizer). |
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Carcinogenicity |
Presumed to have carcinogenic potential for humans |
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Germ cell mutagenicity |
Test Type: Ames test Test system: Salmonella typhimurium Result: negative Remarks: (National Toxicology Program) TTest Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476 Result: negative Test Type: Chromosome aberration test in vitro Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Result: negative Remarks: (ECHA) Test Type: unscheduled DNA synthesis assay Species: Rat Cell type: Liver cells Application Route: Oral Result: negative Remarks: (ECHA) |
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Reproductive toxicity |
No data available |
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Specific target organ toxicity - single exposure |
May cause respiratory irritation. - Respiratory system Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) |
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Special Remarks on other Toxi Effects on Humans |
Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism. |
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Additional Information |
RTECS: AF3675000 Gastrointestinal disturbance To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. After uptake of large quantities: muscular symptoms agitation Convulsions Headache Tremors Nausea psychoses |
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Endocrine disrupting properties |
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Repeated dose toxicity - Rat - male - Oral - 716 Days - NOAEL (No observed adverse effect level) - 9,6 mg/kg Remarks: (ECHA) RTECS: JG8225000 Nausea, Vomiting, Weakness, Dizziness, Vertigo, Headache, Sweating, loss of appetite, Kidney injury may occur., Liver injury may occur. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. The substance has delayed effects. After absorption: Headache Dizziness Nausea The life science business of Merck operates as MilliporeSigma in the US and Canada Vomiting Absorption can result in damage to: Liver Kidney Other dangerous properties can not be excluded. This substance should be handled with particular care. |
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Bioaccumulative potential |
Bioaccumulation Cyprinus carpio (Carp) - 10 mg/l(1,4-Dioxane) Bioconcentration factor (BCF): 0,3 - 0,7 (OECD Test Guideline 305C) |
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Persistence and degradability |
Biodegradability aerobic - Exposure time 29 d Result: < 10 % - Not readily biodegradable. (OECD Test Guideline 301F) |
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Toxicity to fish |
Flow-through test NOEC - Pimephales promelas (fathead minnow) - > 103 mg/l - 32 d Remarks: (ECHA) |
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Toxicity to daphnia and other aquatic invertebrates |
Semi-static test EC50 - Daphnia magna (Water flea) - > 1.000 mg/l - 48 h (OECD Test Guideline 202) |
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Toxicity to algae |
Static test ErC50 - Pseudokirchneriella subcapitata (green algae) - > 1.000 mg/l - 72 h (OECD Test Guideline 201) |
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Products Biodegradation |
The methods for determining the biological degradability are not applicable to inorganic substances. |
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Mobility in soil |
No Information available |
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Results of PBT and vPvB assessment |
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
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Endocrine disrupting properties |
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. |
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Other adverse effects |
Forms toxic mixtures in water, dilution measures notwithstanding. Discharge into the environment must be avoided. |
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Disposal methods |
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. |
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Contaminated packaging |
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. |
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Waste treatment Method |
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions. |
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UN number |
ADR/RID: 1165 IMDG: 1165 IATA: 1165 |
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UN proper shipping name |
ADR/RID:Dioxane IMDG: Dioxane IATA:Dioxane |
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Transport hazard class(es) |
ADR/RID: 3 IMDG: 3 IATA: 3 |
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Packaging group |
ADR/RID: II IMDG: II IATA: II |
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Environmental hazards |
ADR/RID: No IMDG: No IATA: No |
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Special precautions for user |
Tunnel restriction code : (C/E) |
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Further information |
Not classified as dangerous in the meaning of transport regulations. |
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Transport in bulk according to IMOinstruments |
No data available |
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Inventory status |
Components are on the following inventories: Polymaleic acid: - US TSCA, Canadian DSL, EU EINECS, Australian AICS, Korean, Philippine PICCS and Chinese Xi irritant R 36/38 Irritant to eyes & skin R 41 Risk of serious damage to eyes S24/25 Avoid contact with skin and eyes S26/28 In case of contact eyes & skin, rinse with plenty water and seek medical advice Section 312/313: Not listed. Not listed under California proposition 65. |
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Safety, health and environmental regulations/legislation specific for the substance or mixture |
This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006 |
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Safety, health and environmental regulations specific for the product in question |
European Inventory of Existing Commercial Chemical Substances (EINECS) -Listed.EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory- Listed. China Catalog of Hazardous chemicals 2015 Not- Listed. New Zealand Inventory of Chemicals (NZIoC)Listed. PICCS -Listed. Vietnam National Chemical Inventory -Listed. IECSC Listed. Korea Existing Chemicals List (KECL) -Listed. |
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Authorisations and/or restrictions on use |
REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). : 1,4-Dioxane REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII) : 1,4-Dioxane |
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Other regulations |
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. |
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Chemical Safety Assessment |
A Chemical Safety Assessment has been carried out for this substance. |
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Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages.
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
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