EPICHLOROHYDRIN
PURE EPICHLORHYDRIN used extensively as an industrial intermediate, a laboratory reagent, and as an insecticide.
- Part number
- RXSOL-19-1165-035
- Category
- Paint and Cleaning solvent
- Brand
- RXSOL
Overview
Epichlorohydrin is a kind of organochlorine compound as well as epoxide. It can be used as an industrial solvent. It is a highly reactive compound, and can be used for the production of glycerol, plastics, epoxy glues and resins, and elastomers. It can also be used for the production of glycidyl nitrate and alkali chloride, used as the solvent of cellulose, resins, and paint as well as being used as an insect fumigant.
Technical specifications
Physical Properties:
| Melting point | -57 °C |
| Boiling point | 115-117 °C(lit.) |
| Density | 1.183 g/mL at 25 °C(lit.) |
| Vapour density | 3.2 (vs air) |
| Vapour pressure | 13.8 mm Hg ( 21.1 °C) |
| Refractive index | n20/D 1.438(lit.) |
| Flash point | 93 °F |
| Storage temprature | Store below +30°C. |
| Solublity | 65.9g/l |
| Form | Liquid |
| Specific gravity | 1.183 (20/4℃) |
| Explosive limit | 3.8-21%(V) |
| Water solublity | 6 g/100 mL (10 ºC) |
| Dielectric constant | 22.9（20℃） |
| Stability | Unstable. Flammable - note wide explosion limits and low flash point. |
Applications
Applications:
- Epichlorohydrin is mainly used in the production of epoxy resins. It was also used as a solvent for paints, varnishes, lacquers, cellulose esters and ethers, and gums.
- Epichlorohydrin was historically used as an insecticide fumigant.Epichlorohydrin is used to make glycerol,epoxy resins, adhesive, and castings; asderivatives for producing dyes, pharmaceuticals, surfactants, and plasticizers; and asa solvent for resins, gums, paints, andvarnishes.Commercially the most important use is production of glycerine. Large volumes are consumed in nonglycerine areas, which largely consist of the various epoxy resins.
- It has use as a solvent and in the production of epichlorohydrin rubber.Solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. As stabilizer.
Dosage and directions
In biochemistry, it can be used as a crosslinking agent for the production of Sephdex size-exclusion chromatography resins. However, it is a potential carcinogen, and can cause various kinds of side effects on respiratory tract and kidneys. It can be manufactured through the reaction between allyl chloride with hypochlorous acid as well as alcohols.Epoxy resins of the bisphenol A type are synthesized from epichlorhydrin and bisphenol A. This leads to bisphenol-A diglycidyl ether, which is the monomer of bisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers in the epoxy-resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has however been described to occur after contact with a soil fumigant, due to solvent cement and in a worker in a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was used for the production of both drugs propranolol and oxprenolol.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Porduct Name | EPICHLOROHYDRIN |
| Part Number | RXSOL-19-1165-035 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE, OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com | |
| Website | www.rxmraine.com |
| Product name | Cas No | EC No | Weight | Formula |
| Epichlorohydrine | 106-89-8 | 203-439-8 | 92,53 g/mol | C3H5ClO |
| Signal Word | Danger |
| Hazard Statements | H226 Flammable liquid and vapor. H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled. H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H350 May cause cancer. |
| Precautionary statements | P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing |
| Classification of the substance or mixture | No data available |
| Supplemental Hazard Statements | No data available |
| Other hazards | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher |
| General advice | First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance |
| If inhaled | After inhalation: fresh air. Immediately call in physician. If breathing stops immediately apply artificial respiration, if necessary also oxygen. |
| Eye Contact | After eye contact rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses. |
| Swallowed | Give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Do not attempt to neutralise. |
| Skin Contact | In case of skin contact Take off immediately all contaminated clothing. Rinse skin with water/ shower |
| Inhalation | No data available |
| Ingestion | No data available |
| Most important symptoms and effects, both acute and delaye | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Flammability | No data available |
| Suitable extinguishing media | Small (incipient) fires must be extinguished with alcohol resistant foam, dry chemical powder or carbon dioxide. Large amounts of water are ineffective. Cool containers with large amounts of water. |
| Unsuitable extinguishing media | For this substance/mixture no limitations of extinguishing agents are given. |
| Special hazards arising from the substance or mixture | Carbon oxides Hydrogen chloride gas Combustible. Fire may cause evolution of: Hydrogen chloride gas, Phosgene, dioxin Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air at elevated temperatures. Development of hazardous combustion gases or vapours possible in the event of fire |
| Further information | Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system. |
|
Hazardous combustion products |
No data available |
| Advice for firefighters | Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. |
| Protective Equipment | No data available |
| Specific Hazards Arising from the Chemical | No data available |
| Personal precautions, protective equipment and emergency procedures | Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. |
| Spillage | No data available |
| Personal Protection | No data available |
| Enviromental Precaution | Do not let product enter drains. Risk of explosion. |
|
Methods and materials for containment and cleaning |
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area. |
| Reference to other sections | For disposal see section 13. |
| Advice on protection against fire and explosion | Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. |
| Incompatible materials | No data available |
| Hygiene measures | Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. |
| Advice on safe handling | Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols |
| Conditions for safe storage including any incompatibilities |
No data available |
| Storage conditions | Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons. Recommended storage temperature see product label. |
| Storage class | Storage class (TRGS 510) 3 Flammable liquids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| Advice on general occupational hygiene | No data available |
| Exposure controls | Personal protective equipment |
| Engineering Control | No data available |
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses |
| Body Protection | Flame retardant antistatic protective clothing. |
| Skin protection | This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: butyl-rubber Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject® (KCL 898) This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Viton® Minimum layer thickness: 0,7 mm Break through time: 60 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) |
| Respiratory protection |
Recommended Filter type Filter A-(P3) The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
|
| Other Protection Measure | No data available |
| Physical state | Liquid |
| Colour | Colorless |
| Odour | Stinging |
| Odor Threshold | No data available |
| pH | 14 at 100 g/l at 20 °C |
| Melting Point | -57 °C at 1.013 hPa |
| Boiling Point | 117 °C at 1.013 hPa |
| Flash Point | 28 °C - DIN 51755 Part 1 |
| Evaporation Rate | No data available |
| Flammability (solid, gas) | No data available |
| Explosive limits | No data Available |
| Upper/lower flammability or explosive limits | Upper explosion limit 21 %(V) Lower explosion limit 3,8 %(V) |
| Autoignition temperature | 385 °C at 1.013 hPa |
| Decomposition temperature | 225 °C |
| Vapour pressure | 16,5 hPa at 20 °C 22,8 hPa at 25 °C |
| Viscosity | Dynamic: ca.1,03 mPa.s at 20 °C |
| Density | 1,18 g/cm3 at 20 °C |
| Relative Density | 1,18 at 20 °C |
| Specific Gravity | No data available |
| Partition coefficient | Log Pow 0,45 at 25 °C - Bioaccumulation is not expected. |
| Explosive properties | No data available |
| Solubility | ca.65,9 g/l at 25 °C - completely soluble |
| Ignition temperature | No data available |
| Particle characteristics | No data available |
| Reactivity | Vapor/air-mixtures are explosive at intense warming. |
| Chemical stability | The product is chemically stable under standard ambient conditions (room temperature) |
| Possibilityof hazardous reactions | aluminium chloride Amines anilines metallic chlorides Chlorites Tin Zinc Exothermic reaction with: Alkali metals Alcohols alkalines Water Zinc Tin acids Ethyleneimine aromatic amines Nitric acid sulfuric acid trichloroethene |
| Conditions to avoid | Heat, flames and sparks. Heating. |
| Incompatible materials |
No data available
|
| Hazardous decomposition products | In the event of fire: see section 5 |
| Acute toxicity | LD50 Oral - Rat - female - 175 mg/kg (US-EPA) LC50 Inhalation - Rat - female - 4 h - 2,05 mg/l - vapor (ECHA) LD50 Dermal - Rabbit - male and female - 515 mg/kg Remarks: (ECHA) |
| Skin corrosion/irritation | Skin - Rabbit Corrosive (Draize Test) (Regulation (EC) No 1272/2008, Annex VI) Skin - Rabbit Open irritation test - 24 h |
| Serious eye damage/irritation | Eyes - Rabbit Corrosive - 24 h (ECHA) Causes serious eye damage |
| Respiratory or skin sensitization | Maximization Test - Guinea pig positive (OECD Test Guideline 406) May cause sensitization by skin contact. |
| Carcinogenicity | Presumed to have carcinogenic potential for humans |
| Germ cell mutagenicity | Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: positive Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test Metabolic activation: without metabolic activation Method: OECD Test Guideline 476 Result: positive Test Type: Mutagenicity (mammal cell test): chromosome aberration. Species: Mouse Cell type: Bone marrow Application Route: Oral Method: OECD Test Guideline 475 Result: positive Test Type: Mutagenicity (mammal cell test): chromosome aberration. Species: RatCell type: Bone marrow Application Route: inhalation (vapor) Method: OECD Test Guideline 475 Result: Positive results were obtained in some in vivo tests. |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure |
No data available
|
| Additional Information | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Repeated dose toxicity - Rat - male and female - Oral - 90 d - NOAEL (No observed adverse effect level) - 1 mg/kg Remarks: Subchronic toxicity Repeated dose toxicity - Rat - male and female - Inhalation - 88 d Remarks: Subchronic toxicity Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. |
| Persistence and degradability | Biodegradability aerobic - Exposure time 14 d Result: 92,5 % - Readily biodegradable. (OECD Test Guideline 301C) Remarks: (in analogy to similar products) The value is given in analogy to the following substances: 3-chloro1,2-propanediol |
| Toxicity to fish | Static test LC50 - Pimephales promelas (fathead minnow) - 10,6 - 13,2 mg/l - 96 h Remarks: (ECHA) |
| Toxicity to daphnia and other aquatic invertebrates | Static test EC50 - Daphnia magna (Water flea) - 24 mg/l - 48 h Remarks: (ECHA) |
| Toxicity | No data available |
| Toxicity to bacteria | Static test NOEC - microorganisms - 35 mg/l - 72 h Remarks: (ECHA |
| Toxicity to algae | Static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 15 mg/l - 72 h (OECD Test Guideline 201) |
| Products Biodegradation | No data available |
| Mobility in soil | No data availalble |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher |
| Other adverse effects | No data availalble |
| Product | No data available |
| Contaminated packaging | No data available |
| Waste treatment Method | No data available |
| UN number | ADR/RID:2023 | IMDG:2023 |
IATA:2023 |
| UN proper shipping name | ADR/RID:EPICHLOROHYDRIN | IMDG:EPICHLOROHYDRIN | IATA:EPICHLOROHYDRIN |
| Transport hazard class(es) | ADR/RID:6.1 (3) | IMDG:6.1 (3) | IATA:6.1 (3) |
| Packaging group | ADR/RID:ll | IMDG:ll | IATA:ll |
| Environmental hazards | ADR/RID:Yes | IMDG:Yes | IATA:No |
| Special precautions for user | Tunnel restriction code (D/E) | ||
| Further information | No data available |
| Safety,health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
| Other regulations | Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. |
| Chemical Safety Assessment | A Chemical Safety Assessment was not carried out for this substance. |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable. |
