METHANOL GRADIENT GRADE FOR HPLC

Substance / Preparation : Preparation.

Substance

name                                                            Contents                              CAS No 

Pentasodium (carboxylatomethyl) :                       -----                               583-61-9

iminobis(ethylenenitrilo)tetraacetate 

3.1. Classification of the substance or mixture

Classification EC 67/548 or EC 1999/45

Classification : F; R11

T; R23/24/25-R39/23/24/25

Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Health hazards : Specific Target Organ Toxicity - Single exposure - Category 1

- Danger (CLP : STOT SE 1) H370

Acute toxicity, Inhalation - Category 3 - Danger (CLP : Acute Tox. 3) H331

Acute toxicity, Oral - Category 3 - Danger (CLP : Acute Tox. 3) H301

Acute toxicity, dermal - Category 3 - Danger (CLP : Acute Tox. 3) H311

Physical hazards : Flammable solids - Category 1 - Danger (CLP : Flam. Sol. 1) H228

3.2. Label elements

Labelling EC 67/548 or EC 1999/45

Symbol(s) : F : Highly flammable

T : Toxic

R Phrase(s) : R11 : Highly flammable.

R23/24/25 : Toxic by inhalation, in contact with skin and if swallowed.

R39/23/24/25 : Toxic : danger of very serious irreversible effects through inhalation,

in contact with skin and if swallowed.

S Phrase(s) : S7 : Keep container tightly closed.

S16 : Keep away from sources of ignition - No smoking.

S36/37 : Wear suitable protective clothing and gloves.

S45 : In case of accident or if you feel unwell, seek medical advice immediately (show

the label when possible).

Labelling Regulation EC 1272/2008 (CLP)

Hazard pictograms

Signal words : Danger

Hazard statements : H228 : Flammable solid.

H301 : Toxic if swallowed.

H311 : Toxic in contact with skin.

H331 : Toxic if inhaled.

H370 : Causes damage to organ.

Precautionary statements

• Prevention : P240: Ground/bond container and receiving equipment

. P241: Use explosion-proof electrical, ventilating, lighting, …, equipment.

P210: Keep away from heat, sparks, open flames or hot surfaces. – No smoking.

P280: Wear protective gloves, protective clothing, eye protection, face protection.

P271: Use only outdoors or in a well-ventilated area.

P260: Do not breathe dust, fume, gas, mist, vapours, spray.

P264: Wash thoroughly after handling.

P270: Do not eat, drink or smoke when using this product

. • Response : P301+P310: IF SWALLOWED : Immediately call a POISON CENTER or

doctor.

P307+P311: IF EXPOSED : Call a POISON CENTER or doctor.

P302+P352: IF ON SKIN : Wash with plenty of soap and water.

P304+P340: IF INHALED : Remove to fresh air and keep at rest in a position

comfortable for breathing.

P363: Wash contaminated clothing before reuse.

P361: Remove immediately all contaminated clothing.

P370+P378: In case of fire: Use for extinction.

• Storage : P403+P233: Store in well-ventilated place. Keep container tightly closed.

P405: Store locked up.

• Disposal considerations : P501: Dispose of this material and its container to hazardous

or special waste collection point, in accordance with local, regional, national and/or

international regulation.

P501: Dispose of this material and its container to hazardous or special waste

collection point, in accordance with local, regional, national and/or international

regulation.

3.3. Other hazards

Other hazards : The substance does not fulfil the criteria to be identified as PBT

substance or vPvB substance according to Annex XIII of Regulation REACH. 

4.1. Description of first aid measures

Inhalation : Immediately call a POISON CENTER or doctor. Specific treatment (see on

this label). Remove to fresh air and keep at rest in a position comfortable for breathing.

Skin contact : Remove affected clothing and wash all exposed skin area with mild soap

and water, followed by warm water rinse. Wash contaminated clothing before reuse.

Immediately call a POISON CENTER or doctor. Specific treatment (see on this

label). Remove/Take off immediately all contaminated clothing. Wash with plenty of

soap and water

Eye contact : Obtain medical attention if pain, blinking or redness persist. Remove

contact lenses, if present and easy to do. Continue rinsing. Rinse cautiously with water

for several minutes.

Ingestion : Specific treatment (see on this label). Immediately call a POISON CENTER

or doctor. Rinse mouth. Do NOT induce vomiting.

4.2. Most important symptoms and effects, both acute and delayed

Symptoms relating to use : Causes damage to organ.

Repeated exposure to this material can result in absorption through skin causing

significant health hazard. Danger of serious damage to health by prolonged exposure

through inhalation. Swallowing a small quantity of this material will result in serious

health hazard.

4.3. Indication of any immediate medical attention and special treatment needed

General information : Never give anything by mouth to an unconscious person. If you

feel unwell, seek medical advice (show the label where possible). Specific treatment (see

on this label). Call a POISON CENTER or doctor.

5.1. Extinguishing media

Suitable extinguishing media : Foam. Dry powder. Carbon dioxide. Water spray. Sand.

Unsuitable extinguishing media : Do not use a heavy water stream.

Surrounding fires : Use water spray or fog for cooling exposed containers.

5.2. Special hazards arising from the substance or mixture

Flammable class : Flammable solid.

Hazardous combustion products : Under fire conditions, hazardous fumes will

be present.

5.3. Advice for fire-fighters

Protection against fire : Do not enter fire area without proper protective equipment,

including respiratory protection.

Special procedures : Exercise caution when fighting any chemical fire. Avoid (reject)

fire-fighting water to enter environment

6.1. Personal precautions, protective equipment and emergency procedures

For emergency responders : Equip cleanup crew with proper protection.

Ventilate area. Avoid breathing dust, fume, gas, mist, vapours, spray.

Technical measures : Use special care to avoid static electric charges.

Special precautions : Remove ignition sources. No naked lights. No smoking.

For non-emergency personnel : Evacuate unnecessary personnel.

6.2. Environmental precautions

Environmental precautions : Prevent entry to sewers and public waters. Notify

authorities if product enters sewers or public waters.

6.3. Methods and material for containment and cleaning up

Clean up methods : On land, sweep or shovel into suitable containers. Store away from other materials.

6.4. Reference to other sections

See section 8. Exposure controls/personal protection

9.1. Information on basic physical and chemical properties

Physical state at 20 °C : Liquid.

Odour threshold : No data available.

pH value : Not applicable.

Melting point [°C] : -98 °C

Decomposition point [°C] : N/A

Critical temperature [°C] : N/A

Auto-ignition temperature [°C] : N/A

Flammability (solid, gas) : Flammable solid.

Highly flammable liquid and vapour.

Flash point [°C] : 11 °C

Boiling point [°C] : 64.7 °C

Initial boiling point [°C] : N/A

Final boiling point [°C] : N/A

Evaporation rate : N/A

Vapour pressure [20°C] : 96.5 (20° C)

Vapour pressure mm/Hg : N/A

Vapour density : N/A

Density [g/cm3] : 0,8

Relative density, gas (air=1) : 1,1

Relative density, liquid (water=1) : N/A

Solubility in water [% weight] : Complete.

Solubility in water : N/A

Log Pow octanol / water at 20°C : No data available.

Solubility : N/A

Viscosity at 40°C[mm2/s] : N/A

9.2. Other information

Explosive properties : N/A

Explosion limits - upper [%] : 36,50%

Explosion limits - lower [%] : 5,50%

Oxidising properties : No data available.

11.1. Information on toxicological effects

Toxicity information : The product has been not fully tested. The calculated risk has

been done under the requirements of the EU regulations.

Acute toxicity

• Inhalation : Toxic if inhaled.

• Dermal : Toxic in contact with skin.

• Ingestion : Toxic if swallowed.

Corrosion : Based on available data, the classification criteria are not met.

Irritation : Based on available data, the classification criteria are not met.

Sensitization : Based on available data, the classification criteria are not met.

Mutagenicity : Based on available data, the classification criteria are not met.

Carcinogenicity : Based on available data, the classification criteria are not met.

Toxic for reproduction : Based on available data, the classification criteria are not met.

STOT-single exposure : Causes damage to organ.

STOT-repeated exposure : Based on available data, the classification criteria are not met

Aspiration hazard : Based on available data, the classification criteria are not met.

12.1. Toxicity

Toxicity information : The product has been not fully tested. The calculated risk has

been done under the requirements of the EU regulations.

12.2. Persistence - degradability

Persistence - degradability : Biodegradable.

12.3. Bioaccumulative potential

Bioaccumulative potential : Not established.

12.4. Mobility in soil

Mobility in soil : Not established.

12.5. Results of PBT and vPvB assessment

Results of PBT and vPvB assessment : The substance does not fulfil the criteria to be

identified as PBT substance or vPvB substance according to Annex XIII of Regulation REACH.

12.6. Other adverse effects

Environmental precautions : Avoid release to the environment. 

13.1. Waste treatment methods

General : Avoid release to the environment. Dispose in a safe manner in accordance with

local/national regulations. Dispose of this material and its container to hazardous or

special waste collection point, in accordance with local, regional, national and/or

international regulation. Special precautions : Hazardous waste due to toxicity

Handle empty containers with care because residual vapours are flammable.

.

15.1. Safety, health and environmental regulations/legislation specific for the

substance or mixture

Safety, health and environmental : Ensure all national/local regulations are observed.

regulations/legislation specific for the substance or mixture

REACH Restrictions

- Annex XVII : The components of this product are not subject to

restrictions. REACH Authorisation - Annex XIV : The components of this product are not subject to

authorization.

15.2. Chemical Safety Assessment

Chemical Safety Assessment : It has not been carried out

Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic.

vPvB: very persistent and very bioaccumulative

Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN

PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification,

labelling and packaging of substances and mixtures, amending and repealing Directives

67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006

Further information : None.

In accordance with REACH Regulation (CE) Nº 1907/2006 and with CLP Regulation

(CE) Nº 1272/2008 

DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.