NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS
- Part number
- RXSOL-60-6605-027
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides. Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.
Applications
It is commonly used as the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example, as an acid chloride, as illustrated below) and a nucleophilic amine. As DIPEA is hindered and poorly nucleophilic, it does not compete with the nucleophilic amine in the coupling reaction.
Dosage and directions
DIPEA is a good base used for deprotonation of carboxylic acid in peptides/amino acids to give you the intermediate carboxylate. It is added based on molar ratio.
Characteristics and notes
Diisopropylamine is purified by heating to reflux over sodium hydroxide (NaOH) for 3–12 hr, followed by simple distillation from NaOH. 4. Butyllithium in hexanes (2.5 M) is purchased from Aldrich Chemical Company, Inc., and titrated using diphenylacetic acid.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name |
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| Product Type | N,N-DIISOPROPYL ETHYLAMINE FOR SYNTHESIS | ||
| Revised date |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Stock Point : Mumbai, Kandla, Chennai, Visakhapatnam, Kolkata, Fujairah, Muscat Barka
| Phone | +91 22 27815541 / 42 |
| Fax | +91 22 2781 1318 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
2.1. Substance: N,N-DIISOPROPYLETHYLAMINE FOR SYNTHESIS
CAS No : 7087- 68- 5
Substance.
Contains no other components or impurities which will influence the classification of the
product.
3.1. Classification of the substance or mixture
Classification according to Regulation (EC) No. 1272/2008 [CLP]
Flammable liquids, H225
Category 2 Acute toxicity (oral), H301
Category 3
Skin corrosion/irritation, H314
Category 1B
Hazardous to the aquatic environment — Chronic Hazard, H412
Category 3
Classification according to Directive 67/548/EEC or 1999/45/EC
Adverse physicochemical, human health and environmental effects
No additional information available
3.2. Label elements
Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to
displayExtra classification(s) to display
Symbol(s) : Highly flammable
C: Corrosive
R Phrase(s) : R11: Highly flammable.
R22: Harmful if swallowed.
R34: Cause burns.
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
S Phrase(s) : S16: Keep away from source of ignition-No smoking.
S26: In the case of contact with eyes, rinse immediately with plenty of water and seek
medical advise.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the
label where possible).
S61: avoid release to the environment . refer to special instruction/safety data sheets.
S36/37/39 : Wear suitable protective clothing and gloves & eye/face protecting.
Hazard pictograms
Signal word : Danger
Hazard statements : H225 - Highly flammable liquid and vapour
H301 - Toxic if swallowed
H314 - Causes severe skin burns and eye damage
H412 - Harmful to aquatic life with long lasting effects
Precautionary statements : P210 - Keep away from heat, hot surfaces, sparks, open
flames and other ignition
sources. No smoking
P273 - Avoid release to the environment
P280 - Wear protective gloves, protective clothing, eye protection, face protection
P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER/doctor/…
3.3. Other hazards No additional information available
4.1. Description of first aid measures
First-aid measures after inhalation : Remove victim to fresh air and keep at rest in a
position comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
First-aid measures after skin contact : Remove affected clothing and wash all exposed
skin area with mild soap and water, followed by warm water rinse. Wash with plenty of
soap and water. Immediately call a POISON CENTER or doctor/physician.
First-aid measures after eye contact : Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a
POISON CENTER or doctor/physician.
First-aid measures after ingestion : Rinse mouth. Do NOT induce vomiting. Immediately
call a POISON CENTER or doctor/physician.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms/injuries : Causes severe skin burns and eye damage.
Symptoms/injuries after ingestion : Swallowing a small quantity of this material will
result in serious health hazard.
4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically.
5.1. Extinguishing media
Suitable extinguishing media : Carbon dioxide. Dry powder. Foam. Water spray.
Unsuitable extinguishing media : Do not use a heavy water stream.
5.2. Special hazards arising from the substance or mixture
Fire hazard : Highly flammable liquid and vapour.
Explosion hazard : May form flammable/explosive vapour-air mixture.
5.3. Advice for firefighters
Protection during firefighting : Do not enter fire area without proper protective
equipment, including respiratory protection.
6.1. Personal precautions, protective equipment and emergency procedures
General measures : Remove ignition sources. Use special care to avoid static
electric charges. No naked lights. No smoking
6.1.1. For non-emergency personnel
Emergency procedures : Evacuate unnecessary personnel.
6.1.2. For emergency responders
Protective equipment : Use personal protective equipment as required.
Emergency procedures : Ventilate area.
6.2. Environmental precautions Avoid release to the environment.
6.3. Methods and material for containment and cleaning up
Methods for cleaning up : Collect spillage. On land, sweep or shovel into suitable
containers.
6.4. Reference to other sections
No additional information available
7.1. Precautions for safe handling
Additional hazards when processed : Handle empty containers with care because residual
vapours are flammable.
Precautions for safe handling : Avoid contact with skin and eyes. Use only non-sparking
tools. Keep away from sources of ignition - No smoking. Do not breathe vapours.
Provide good ventilation in process area to prevent formation of vapour.
Hygiene measures : Do not eat, drink or smoke when using this product. Wash hands and
other exposed areas with mild soap and water before eating, drinking or smoking and
when leaving work.
7.2. Conditions for safe storage, including any incompatibilities
Technical measures : Proper grounding procedures to avoid static electricity should be
followed.
Ground/bond container and receiving equipment. Use explosion-proof
electrical/ventilating/lighting/… equipment. Comply with applicable regulations.
Storage conditions : Keep in fireproof place. Keep container tightly closed.
Incompatible materials : Heat sources.
7.3. Specific end use(s)
No additional information available
8.1. Control parameters
No additional information available
8.2. Exposure controls
Hand protection : Protective gloves
Eye protection : Chemical goggles or face shield
Skin and body protection : Wear suitable protective clothing
Respiratory protection : Wear respiratory protection
9.1. Information on basic physical and chemical properties
Odour threshold : No data available
pH : 12.3
Relative evaporation rate (butylacetate=1) : No data available
Melting point : -50 °C
Freezing point : No data available
Boiling point : 127 °C
Flash point : 10.6 °C
Auto-ignition temperature : No data available
Decomposition temperature : No data available
Flammability (solid, gas) : Flammable
Highly flammable liquid and vapour
Vapour pressure : 16 hPa at 20 °C
Relative vapour density at 20 °C : No data available
Relative density : No data available
Density : 0.742 g/cm³
Solubility : No data available
Log Pow : No data available
Viscosity, kinematic : No data available
Viscosity, dynamic : No data available
Explosive properties : No data available
Oxidising properties : No data available
Explosive limits : 0.007 - 0.063 vol %
9.2. Other information
No additional information available
10.1. Reactivity
Thermal decomposition generates : Corrosive vapours.
10.2. Chemical stability
Stable under normal conditions.
10.3. Possibility of hazardous reactions
No additional information available
10.4. Conditions to avoid
Open flame. Heat. Sparks.
10.5. Incompatible materials
No additional information available
10.6. Hazardous decomposition products
May release flammable gases. Thermal decomposition generates : Corrosive vapours.
11.1. Information on toxicological effects
Acute toxicity : Oral: Toxic if swallowed.
Skin corrosion/irritation : Causes severe skin burns and eye damage.
pH: 12.3
Serious eye damage/irritation : Serious eye damage, category 1, implicit
pH: 12.3
Respiratory or skin sensitisation : Not classified
Germ cell mutagenicity : Not classified
Carcinogenicity : Not classified
Reproductive toxicity : Not classified
Specific target organ toxicity (single exposure) : Not classified
Specific target organ toxicity (repeated exposure) : Not classified
Aspiration hazard : Not classified
Potential adverse human health effects and symptoms : Harmful if swallowed.
12.1. Toxicity
Ecology - water : Harmful to aquatic life with long lasting effects.
12.2. Persistence and degradability
Persistence and degradability May cause long-term adverse effects in the environment.
12.3. Bioaccumulative potential
No additional information available
12.4. Mobility in soil
No additional information available
12.5. Results of PBT and vPvB assessment
No additional information available
12.6. Other adverse effects
No additional information available
13.1. Waste treatment methods
Product/Packaging disposal
Recommendations : Dispose of contents/container to ...
Additional information : Handle empty containers with care because residual vapours are
flammable.
In accordance with ADR / RID / IMDG / IATA / ADN
14.1. UN number
UN-No. (ADR) : 2733
UN-No. (IMDG) : 2733
UN-No.(IATA) : 2733
UN-No.(ADN) : 2733
UN-No. (RID) : 2733
14.2. UN proper shipping name
Proper Shipping Name (ADR) : AMINES, FLAMMABLE, CORROSIVE, N.O.S. /
POLYAMINES, FLAMMABLE, CORROSIVE, N.O.S.
Proper Shipping Name (IMDG) : AMINES, FLAMMABLE, CORROSIVE, N.O.S.
Proper Shipping Name (IATA) : AMINES, FLAMMABLE, CORROSIVE, N.O.S.
Proper Shipping Name (ADN) : AMINES, FLAMMABLE, CORROSIVE, N.O.S.
Proper Shipping Name (RID) : AMINES, FLAMMABLE, CORROSIVE, N.O.S.
Transport document description (ADR) : UN 2733 AMINES, FLAMMABLE,
CORROSIVE, N.O.S. / POLYAMINES,
FLAMMABLE, CORROSIVE, N.O.S., 3 (8), II, (D/E)
Transport document description (IMDG) : UN 2733 AMINES, FLAMMABLE,
CORROSIVE, N.O.S., 3 (8), II
Transport document description (IATA) : UN 2733 AMINES, FLAMMABLE,
CORROSIVE, N.O.S., 3 (8), II
Transport document description (ADN) : UN 2733 AMINES, FLAMMABLE,
CORROSIVE, N.O.S., 3 (8), II
Transport document description (RID) : UN 2733 AMINES, FLAMMABLE,
CORROSIVE, N.O.S., 3 (8), II
14.3. Transport hazard class(es)
ADR- Transport hazard class(es) (ADR) : 3 (8)
Danger labels (ADR) : 3, 8
IMDG- Transport hazard class(es) (IMDG) : 3 (8)
Danger labels (IMDG) : 3, 8
IATA- Transport hazard class(es) (IATA) : 3 (8)
Hazard labels (IATA) : 3, 8
ADN- Transport hazard class(es) (ADN) : 3 (8)
Danger labels (ADN) : 3, 8
RID- Transport hazard class(es) (RID) : 3 (8)
Danger labels (RID) : 3, 8
14.4. Packing group
Packing group (ADR) : II
Packing group (IMDG) : II
Packing group (IATA) : II
Packing group (ADN) : II
Packing group (RID) : II
14.5. Environmental hazards
Dangerous for the environment : No
Marine pollutant : No
Other information : No supplementary information available
14.6. Special precautions for user
Overland transport- Classification code (ADR) : FC
Special provision (ADR) : 274, 544
Limited quantities (ADR) : 1L
Excepted quantities (ADR) : E2
Packing instructions (ADR) : P001, IBC02
Mixed packing provisions (ADR) : MP19
Portable tank and bulk container instructions (ADR) : T11
Portable tank and bulk container special provisions (ADR) : TP1, TP27
Tank code (ADR) : L4BH
Vehicle for tank carriage : FL
Transport category (ADR) : 2
Special provisions for carriage – Operation (ADR) : S2, S20
Hazard identification number (Kemler No.) : 338
Orange plates :
Tunnel restriction code (ADR) : D/E
EAC code : •2WE
APP code : A(fl)
Transport by sea- Special provision (IMDG) : 274
Limited quantities (IMDG) : 1 L
Excepted quantities (IMDG) : E2
Packing instructions (IMDG) : P001
IBC packing instructions (IMDG) : IBC02
Tank instructions (IMDG) : T11
Tank special provisions (IMDG) : TP1, TP27
EmS-No. (Fire) : F-E
EmS-No. (Spillage) : S-C
Stowage category (IMDG) : B
Stowage and handling (IMDG) : SW2
Segregation (IMDG) : SG35
MFAG-No : 132
Air transport- PCA Excepted quantities (IATA) : E2
PCA Limited quantities (IATA) : Y340
PCA limited quantity max net quantity (IATA) : 0.5L
PCA packing instructions (IATA) : 352
PCA max net quantity (IATA) : 1L
CAO packing instructions (IATA) : 363
CAO max net quantity (IATA) : 5L
Special provision (IATA) : A3
ERG code (IATA) : 3C
Inland waterway transport- Classification code (ADN) : FC
Special provisions (ADN) : 274, 544
Limited quantities (ADN) : 1 L
Excepted quantities (ADN) : E2
Carriage permitted (ADN) : T
Equipment required (ADN) : PP, EP, EX, A
Ventilation (ADN) : VE01
Number of blue cones/lights (ADN) : 1
Rail transport- Classification code (RID) : FC
Special provision (RID) : 274, 544
Limited quantities (RID) : 1L
Excepted quantities (RID) : E2
Packing instructions (RID) : P001, IBC02
Mixed packing provisions (RID) : MP19
Portable tank and bulk container instructions (RID) : T11
Portable tank and bulk container special provisions (RID) : TP1, TP27
Tank codes for RID tanks (RID) : L4BH
Transport category (RID) : 2
Colis express (express parcels) (RID) : CE7
Hazard identification number (RID) : 338
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable
15.1. Safety, health and environmental regulations/legislation specific for the
substance or mixture
15.1.1. EU-Regulations
No REACH Annex XVII restrictions
N,N-DIISOPROPYLETHYLAMINE FOR SYNTHESIS is not on the REACH
Candidate List
N,N-DIISOPROPYLETHYLAMINE FOR SYNTHESIS is not on the REACH Annex
XIV List
15.1.2. National regulations
Germany
12th Ordinance Implementing the Federal
Immission Control Act - 12.BImSchV : Is not subject of the 12. BlmSchV (Hazardous
Incident Ordinance)
Denmark
Class for fire hazard : Class I-1
Store unit : 1 liter
Classification remarks : F ; Emergency management guidelines for the
Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic.
vPvB: very persistent and very bioaccumulative
Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN
PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification,
labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Further information : None.
In accordance with REACH Regulation (CE) Nº 1907/2006 and with CLP Regulation
(CE) Nº 1272/2008
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
Availability
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