NO DIMETHYL HYDROXYLAMINE HYDROCHLORIDE FOR SYNTHESIS
- Part number
- RXSOL-60-6605-035
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
N,O-Dimethylhydroxylamine is a methylated hydroxylamine used to form so called 'Weinreb amides' for use in the Weinreb ketone synthesis.[2] It is commercially available as its hydrochloride salt.
Applications
N,O-Dimethylhydroxylamine is a methylated hydroxylamine used to form so called 'Weinreb amides' for use in the Weinreb ketone synthesis. It is commercially available as its hydrochloride salt.
Characteristics and notes
It may be prepared by reacting ethyl chloroformate (or similar) with hydroxylamine followed by treatment with a methylating agent such as dimethyl sulfate. The N,O-dimethylhydroxylamine is then liberated by acid hydrolysis followed by neutralization.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | NO DIMETHYL HYDROXYLAMINE HYDROCHLORIDE FOR SYNTHESIS |
| Part Number | RXSOL-60-6605-035 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 2087 1500 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
| Chemical Name | CAS | EC number | Weight % |
|
NO DIMETHYL HYDROXYLAMINE HYDROCHLORIDE FOR SYNTHESIS |
6638-79-5 | 229-642-1 | 100% |
| Signal Word | Warning |
| Hazard Statements | H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. |
| Precautionary statements - response |
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continuerinsing.
|
| Supplemental Hazard Statements | None |
| Other hazards | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or highe |
| General advice | Show this material safety data sheet to the doctor in attendance. |
| If inhaled | After inhalation: fresh air. |
| In case of skin contact | In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. |
| Eye Contact | After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. |
| Skin Contact | Get medical attention. Wash off immediately with plenty of water for at least 15 minutes |
| Inhalation: | Remove to fresh air. If breathing is difficult, give oxygen. Get medical attention. |
| Ingestion: | Do NOT induce vomiting. Get medical attention. |
| Notes to Physician | No information available |
| If swallowed | After swallowing: immediately make victim drink water (two glasses at most). Consult a physician. |
| Most important symptoms and effects, both acute and delaye | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Extinguishing media | No information available |
| Flammability | 1 |
| Flash Point | No information available |
| Suitable extinguishing media | Water Foam Carbon dioxide (CO2) Dry powder |
| Unsuitable extinguishing media | For this substance/mixture no limitations of extinguishing agents are given. |
| Special hazards arising from the substance or mixture |
Carbon oxides
Nitrogen oxides (NOx)
Hydrogen chloride gas
Combustible.
Fire may cause evolution of:
Nitrogen Oxides, Hydrogen chloride gas
Development of hazardous combustion gases or vapours possible in the event of fire
|
| Further information | Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fireextinguishing water from contaminating surface water or the ground water system. |
| Hazardous combustion products | NA |
| Advice for firefighters | Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. |
| Protective Equipment | As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear |
| Specific Hazards Arising from the Chemical | Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition |
| Personal precautions, protective equipment and emergency procedures |
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures,
consult an expert. For personal protection see section 8.
|
| Spillage | NA |
| Personal Protection | NA |
| Enviromental Precaution | Do not let product enter drains. |
|
Methods and materials for containment and cleaning |
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts. |
| Precautions for safe handling | For precautions see section 2.2. |
| Conditions for safe storage, including any incompatibilities Storage conditions |
Tightly closed. Dry.
Recommended storage temperature see product label.
|
| Handling | Wear personal protective equipment/face protection. Avoid dust formation. Do not get in eyes, on skin, or on clothing. Ensure adequate ventilation. Avoid ingestion and inhalation. |
| Storage. | Storage class (TRGS 510): 11: Combustible Solids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| Occupational Exposure limit values | This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies. |
| Biological limit values | No data available |
| Exposure controls | No data available |
| Engineerin Measures | Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. |
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses |
| Body Protection |
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing.The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace |
| Skin protection |
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
|
| Respiratory protection | Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced |
| Other Protection Measure | Handle in accordance with good industrial hygiene and safety practice. |
| Contro Of environmental exposure | NA |
| Hygiene Measures | Handle in accordance with good industrial hygiene and safety practice |
Gloves Suit
| Physical state | Powder Solid |
| Colour | White |
| Odour | NA |
| Odor Threshold | No information available |
| pH | NA |
| Melting Point | NA |
| Initial boiling point and boiling range | NA |
| Boiling Point | NA |
| Flash Point | NA |
| Evaporation Rate | Not Applicable |
| Flammability (solid, gas) | No data available |
| Explosive limits | No Data Available |
| Upper/lower flammability or explosive limits | No data available |
| Autoignition temperature | No data available |
| Decomposition temperature | No data available |
| Vapour pressure | No Data Available |
| Density | No data available |
| Vapour Density | No Data Available |
| Specific Gravity | No data available |
| Upper/lower flammability or explosive limits | NA |
| Vapour density | NA |
| Vapour pressure | NA |
| Partition coefficient | No data available |
| Auto-ignition emperature | NA |
| Explosive properties | None |
| Solubility | NA |
| Molecular Weight | NA |
| Molecular Formula | NA |
| Reactivity | The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. |
| Stability | The product is chemically stable under standard ambient conditions (room temperature). |
| Possibility of hazardous reactions |
Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!
Violent reactions possible with:
Strong oxidizing agents
|
| Conditions to avoid | Avoid dust formation. Incompatible products. Excess heat. |
| Incompatible materials | Strong oxidizing agents |
| HazardousPolymerization | Hazardous polymerization does not occur. |
| Hazardous Reactions | None under normal processing. |
| Acute toxicity |
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gas trointestinal tract. Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
|
| Skin corrosion/irritation |
NA |
| Serious eye damage/eye irritation |
NA |
| Respiratory or skin sensitization | NA |
| Serious eye damage/eye irritation | No data available |
| Rout Of Entry | Inhalation. Ingestion. |
| Toxicity to Animal | NA |
| Toxic Effects on Human | NA |
| Germ cell mutagenicity |
NA |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure | No data available |
| Other Adverse Effects | The toxicological properties have not been fully investigated |
| Persistence and degradability | No data available |
| Toxicity | TNo data available |
| Bioaccumulative potential | No data available |
| Toxicity to fish | No data available |
| Toxicity to daphnia and other aquatic invertebrates | No data available |
| Toxicity to algae | No data available |
| Eco Toxicity | Not Available |
| COD and BOD 5 | Not Available |
| Products Biodegradation: |
No data available |
| Mobility in soil | No data available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. |
| Assessment | No data available |
| Other adverse effects | Discharge into the environment must be avoided. |
| Disposal methods | Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification |
| Contaminated packaging | NA |
| Waste treatment Method |
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions |
| UN number | NA |
| UN proper shipping name |
No data available |
| Transport hazard class(es) |
No data available |
| Packaging group |
No data available |
| Environmental hazards |
No data available |
| Special precautions for user | No data available |
| Further information | Not classified as dangerous in the meaning of transport regulations. |
| Transport in bulk according to IMOinstruments | No data available |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
| Safety, health and environmental regulations specific for the product in question | NA |
| National legislation | NA |
| DSCL (EEC) | NA |
| Other regulations | Take note of Dir 94/33/EC on the protection of young people at work. |
| Chemical Safety Assessment | For this product a chemical safety assessment was not carried out |
| Other Information |
Full text of H-Statements referred to under sections 2 and 3. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 Causes skin irritation. |
|
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages.
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages.
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages.
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
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Availability
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