PHTHALIDE FOR SYNTHESIS
- Part number
- RXSOL-60-6605-250
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
Phthalide is an organic chemical compound with the molecular formula C8H6O2. It is a lactone that serves as the core chemical structure for a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).
Applications
Phthalide is used in the synthesis of several pharmaceutical drugs including isoxepac, vatalanib, and hydralazine as well as the pesticide kresoxim-methyl .
Dosage and directions
administered for three days at doses of 10 or 40
Characteristics and notes
1. In checking these directions complete failure was repeatedly encountered with good commercial grades of zinc dust, and only when the metal was activated with copper sulfate did reduction proceed at all.
2. The mother liquor, on concentrating to less than half its volume, yields no further crystals on chilling.
3. On cooling, a minute amount of a yellow impurity separates with the phthalide at the beginning of crystallization. This impurity apparently cannot be eliminated by boiling with charcoal but is present in too small amount to affect the melting point of the product.
4. Concentration of the final mother liquor to a volume of 500 cc. yields a further small quantity of phthalide, but this operation is scarcely worth while.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | PHTHALIDE FOR SYNTHESIS |
| Part Number | RXSOL-60-6605-250 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com | |
| Website | www.rxmraine.com |
| Chemical Name | CAS | EC number | Weight |
| Phthalide for synthesis | 17369-59-4 | 241-402-8 | 100% |
| Signal Word | Warning |
| Classification of the substance or mixture | Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Long-term (chronic) aquatic hazard (Category 3), H412 |
| Hazard Statements |
H302 Harmful if swallowed. H317 May cause an allergic skin reaction. |
| Precautionary statements | P280 Wear protective gloves. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth. P302 + P352 IF ON SKIN: Wash with plenty of water. |
| Response | None |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
| Prevention | P273 Avoid release to the environment. |
| Supplemental Hazard Statements | None |
| Other hazards | No additional information available |
| General advice | Consult a physician. Show this material safety data sheet to the doctor in attendance. |
| If inhaled | If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician |
| Eye Contact | Flush eyes with water as a precaution.. |
| Swallowed | Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. |
| Skin Contact | Wash off with soap and plenty of water. Consult a physician |
| Inhalation | Move to fresh air. Assure fresh air breathing. |
| Ingestion | Rinse mouth. Prolonged medical observation may be indicated. |
| Notes to Physician | Treat symptomatically |
| Most important symptoms and effects, both acute and delaye | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Flammability | May be combustible at high temperature. |
| Flash Point | Higher than 93.3°C (200°F). |
| Suitable extinguishing media | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
| Unsuitable extinguishing media | For this substance/mixture no limitations of extinguishing agents are given. |
| Special hazards arising from the substance or mixture | Carbon oxides Carbon oxides |
| Further information | No data available |
|
Hazardous combustion products |
Fire may cause the evolution of Sulphur oxides, nitrogen oxides. |
| Advice for firefighters | Wear self-contained breathing apparatus for firefighting if necessary |
| Protective Equipment | Use personal protective equipment. |
| Specific Hazards Arising from the Chemical |
Has a fire-promoting effect due to the release of oxygen. Ambient fire may liberate hazardous vapours. |
| Personal precautions, protective equipment and emergency procedures | Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. For personal protection see section 8. |
| Spillage | Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal. |
| General measures | Avoid any direct contact with the product. Do not breathe dust/fume/gas/mist/vapours/spray. |
| Personal Protection | Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: Protective equipment see section 8. |
| Enviromental Precaution | Do not let product enter drains. |
| Methods and materials for containment and cleaning | Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. |
| Reference to other sections | For disposal see section 13. |
| Advice on safe handling | Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. |
| Additional hazards when processed | The attention of the user is drawn to the risks possibly incurred by using the product for any other purpose than that for which it was intended. |
| Advice on protection against fire and explosion | Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. |
| Hygiene measures | Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. For precautions see section 2.2. |
| Precautions for safe handling | Material should be handled with caution. Avoid any direct contact with the product. Material should be handled in a laboratory hood whenever possible. |
| Conditions for safe storage, including any incompatibilities | Technical measures : Comply with applicable regulations. Storage conditions : Store locked up. |
| Storage conditions | Keep container tightly closed in a dry and well-ventilated place. Store in cool place. |
| Storage class | Storage class (TRGS 510): 10: Combustible liquids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| Handling | Keep away from heat. Keep away from sources of ignition. Keep away from combustible material.. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as reducing agents, combustible materials, organic materials, metals |
| Advice on general occupational hygiene | Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance. |
| Occupational Exposure limit values | No data available |
| Biological limit values | No data available |
| Exposure controls | Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the riskelimination area |
| Engineering Control | Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. |
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses |
| Body Protection and body protection | Use chemically protective clothing. DIN EN 13034 |
| Respiratory protection | Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). |
| Other Protection Measure | Handle in accordance with good industrial hygiene and safety practice. |
| Control of environmental exposure | Do not let product enter drains. |
| Thermal hazards | No data available |
| Physical state | Liquid |
| Colour | No data available |
| Odour | No data available |
| Odor Threshold | Not Applicable |
| pH | No data available |
| Melting Point | Melting point/range: 5 °C - lit |
| Boiling Point | 170 °C at 16 hPa - lit. |
| Flash Point | 113 °C - closed cup |
| Evaporation Rate | Not Applicable |
| Flammability (solid, gas) | No data available |
| Explosive limits | No Data Available |
| Upper/lower flammability or explosive limits | 13,4 %(V)/2,6 %(V) |
| Autoignition temperature | 402 °Cat at1.013 hPa |
| Dynamic Viscosity | No data available |
| Decomposition temperature | No data available |
| Vapour pressure | 113 hPa at 20 °C |
| Density | 1,122 g/mL at 25 °C - lit. |
| Vapour Density | No Data Available |
| Specific Gravity | No data available |
| Partition coefficient | 0,73 at 25 °C |
| Explosive properties | None |
| Solubility | 20 g/l at 20 °C |
| Particle characteristics | No data available |
| Surface tension | No data available |
| Relative vapor density | No data available |
| Reactivity | No data available |
| Stability | Stable under recommended storage conditions |
| Possibility of hazardous reactions | No data available |
| Conditions to avoid | Warming. |
| Incompatible materials | Strong oxidizing agents |
| Hazardous decomposition products | In the event of fire: see section 5 |
| Acute toxicity | LD50 Oral - Rat - 1.650 mg/kg Inhalation: No data available Dermal: No data available |
| Skincorrosion/irritation | Remarks: Mild skin irritation |
| Serious eye damage/eye irritation | Remarks: No data available |
| Respiratory or skin sensitization | May cause sensitization by skin contact. |
| Serious eye damage/eye irritation | Test system: S. typhimurium Result: Not mutagenic in Ames Test. |
| Toxicity to Animal | WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE Acute oral toxicity (LD50): 689 mg/kg [Rat]. |
| Toxic Effects on Human | May cause damage to the following organs: upper respiratory tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant, lung sensitizer). |
| Germ cell mutagenicity | Test Type: Ames test Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Human lymphocytes Metabolic activation: without metabolic activation Method: OECD Test Guideline 473 Result: positive Test Type: Micronucleus test Test system: human lymphoblastoid cells Metabolic activation: without metabolic activation Method: OECD Test Guideline 487 Result: negative Test Type: In vitro mammalian cell gene mutation test Test system: human lymphoblastoid cells Metabolic activation: without metabolic activation Method: OECD Test Guideline 490 Result: positive |
| Carcinogenicity | No data available |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure | May cause respiratory irritation. - Respiratory system |
| Special Remarks on other Toxi Effects on Humans | Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism. |
| Aspiration hazard | No data available |
| Additional Information | irritant effects To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. |
| Persistence and degradability | Biodegradability aerobic - Exposure time 14 d Result: 82 - 98 % - Readily biodegradable. (OECD Test Guideline 301C) |
| Toxicity | No data available |
| Bioaccumulative potential | No data available |
| Toxicity to fish | flow-through test NOEC - Pimephales promelas (fathead minnow) - 0,55 mg/l - 34 d (OECD Test Guideline 210) |
| Toxicity to daphnia and other aquatic invertebrates | static test EC50 - Daphnia magna (Water flea) - 12,6 mg/l - 48 h (OECD Test Guideline 202) |
| Toxicity to algae | ErC50 - Pseudokirchneriella subcapitata - 12,7 mg/l - 72 h (OECD Test Guideline 201) |
| Toxicity to bacteria | Static test NOEC - activated sludge - 1.995 mg/l - 30 min (OECD Test Guideline 209) |
| COD and BOD 5 | Not Available |
| Products Biodegradation | The methods for determining the biological degradability are not applicable to inorganic substances. |
| Mobility in soil | No Information available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher |
| Other adverse effects | No data available |
| Disposal methods | The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. |
| Contaminated packaging | Dispose of as unused product. |
| Waste treatment Method | Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. |
| UN number | ADR/RID: - IMDG: - IATA: - |
| UN proper shipping name |
ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods |
| Transport hazard class(es) | ADR/RID: - IMDG: - IATA: - |
| Packaging group | ADR/RID: IMDG: IATA: |
| Environmental hazards | ADR/RID: No IMDG: No IATA: No |
| Special precautions for user | Tunnel restriction code : (C/E) |
| Further information | Not classified as dangerous in the meaning of transport regulations. |
| Transport in bulk according to IMOinstruments | No data available |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006 |
| Safety, health and environmental regulations specific for the product in question | European Inventory of Existing Commercial Chemical Substances (EINECS) -Listed.EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory- Listed. China Catalog of Hazardous chemicals 2015 Not- Listed. New Zealand Inventory of Chemicals (NZIoC)Listed. PICCS -Listed. Vietnam National Chemical Inventory -Listed. IECSC Listed. Korea Existing Chemicals List (KECL) -Listed. |
| National legislation | Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ACUTE TOXIC : ENVIRONMENTAL HAZARDS |
| DSCL (EEC) | R8- Contact with combustible material may cause fire. R20/22- Harmful by inhalation and if swallowed. R36/37/38- Irritating to eyes, respiratory system and skin. R42/43- May cause sensitization by inhalation and skin contact. S22- Do not breathe dust. S24- Avoid contact with skin. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37- Wear suitable gloves. |
| Other regulations | Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable.Take note of Dir 94/33/EC on the protection of young people at work. |
| Chemical Safety Assessment | For this product a chemical safety assessment was not carried out |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable. |
Availability
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