POLYVINYL PYRROLIDONE PVP
- Part number
- RXSOL-60-6605-241
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
Polyvinylpyrrolidone, also known as povidone or PVP, is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.N-vinyl-2-pyrrolidone (VP) is commonly used as a reactive diluent for radiation curing in UV-coating, UV-inks, and UV- adhesives.
Applications
Polyvinylpyrrolidone (PVP), commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone [87,88]. Dry PVP is a light flaky hygroscopic powder and readily absorbs up to 40% of water by its weight. ... The PVP was used as a blood plasma expander for trauma victims.
Dosage and directions
Polyvinylpyrrolidone, also known as povidone or PVP, is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Characteristics and notes
In brief, the PVP solution was prepared by dissolving 0.5 g of PVP in 10 mL of deionized water at room temperature for 2 h under agitation. The PVP/CNC ratio was controlled by stoichiometric addition of a CNC suspension to a fixed quantity of the PVP solution followed by vigorous stirring for 1 h.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | POLYVINYL PYRROLIDONE |
| Part Number | RXSOL-60-6605-241 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com | |
| Website | www.rxmraine.com |
| Chemical Name | CAS | EC number | Weight | Formula |
| Polyvinylpyrrolidone | 9003-39-8 | -- | <= 100 % | (C6H9NO)x |
| Signal Word | None |
| Hazard Statements | H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled. H373 May cause damage to organs (Kidney) through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects. |
| Precautionary statements | P262 Do not get in eyes, on skin, or on clothing. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing. P302 + P352 + P310 IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/ doctor. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P314 Get medical advice/ attention if you feel unwell. |
| Classification of the substance or mixture | Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008. |
| Supplemental Hazard Statements | None |
| Other hazards | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| General advice | None |
| If inhaled | If breathed in, move person into fresh air. If not breathing, give artificial respiration. |
| Eye Contact | Flush eyes with water as a precaution. |
| Swallowed | Never give anything by mouth to an unconscious person. Rinse mouth with water. |
| Skin Contact | Wash off with soap and plenty of water. |
| Inhalation | Remove patient to fresh air, keep warm and at rest and get medical assistance in necessary. |
| Ingestion | Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately. |
| Most important symptoms and effects, both acute and delaye | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Flammability | May be combustible at high temperature. |
| Suitable extinguishing media | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
| Unsuitable extinguishing media | For this substance/mixture no limitations of extinguishing agents are given.. |
| Special hazards arising from the substance or mixture | Carbon oxides Nitrogen oxides (NOx) |
| Further information | No data available |
|
Hazardous combustion products |
Fire may cause the evolution of Sulphur oxides, nitrogen oxides. |
| Advice for firefighters | Wear self-contained breathing apparatus for firefighting if necessary. |
| Protective Equipment | Use personal protective equipment. |
| Specific Hazards Arising from the Chemical |
Has a fire-promoting effect due to the release of oxygen. Ambient fire may liberate hazardous vapours. |
| Personal precautions, protective equipment and emergency procedures | Avoid dust formation. Avoid breathing vapors, mist or gas.For personal protection see section 8. |
| Spillage | Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal. |
| Personal Protection | Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: Protective equipment see section 8. |
| Enviromental Precaution | No special environmental precautions required. |
|
Methods and materials for containment and cleaning |
Sweep up and shovel. Keep in suitable, closed containers for disposal. |
| Reference to other sections | For disposal see section 13. |
| Advice on safe handling | Work under hood. Do not inhale substance/mixture. |
| Advice on protection against fire and explosion | Provide appropriate exhaust ventilation at places where dust is formed. |
| Incompatible materials | Keep away from alkalis, strong oxidizing agents and metals. Provide containment walls of adequate capacity to hold any accidental spills. |
| Hygiene measures | General industrial hygiene practice. For precautions see section 2.2. |
| Precautions for safe handling | For precautions see section 2.2. |
| Conditions for safe storage, including any incompatibilities | Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. |
| Storage conditions | Keep container tightly closed in a dry and well-ventilated place. Store in cool place. hygroscopic |
| Storage class | Storage class (TRGS 510): 11: Combustible Solids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| Advice on general occupational hygiene | Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance. |
| Exposure controls | No specific additional engineering controls are required. Provide good natural or artificial ventilation. |
| Engineering Control | Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. |
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). |
| Body Protection | Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. |
| Skin protection | Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. |
| Respiratory protection | Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). |
| Other Protection Measure | Handle in accordance with good industrial hygiene and safety practice. |
| Control of environmental exposure | No special environmental precautions required. |
Gloves Suit
| Physical state | Powder |
| Colour | Beige |
| Odour | No data available |
| Odor Threshold | Not Applicable |
| pH | 5,0 - 8 at 10 g/l at 20 °C |
| Melting Point | No data available |
| Boiling Point | No data available |
| Flash Point | Not Applicable |
| Evaporation Rate | Not Applicable |
| Flammability (solid, gas) | No data available |
| Explosive limits | No Data Available |
| Upper/lower flammability or explosive limits | No data available |
| Autoignition temperature | No data available |
| Decomposition temperature | No data available |
| Vapour pressure | No data available |
| Density | No data available |
| Relative Density | No data available |
| Freezing point | No data available |
| Specific Gravity | No data available |
| Partition coefficient | No data available |
| Explosive properties | No data available |
| Solubility | No data available |
| Ignition temperature | No information available. |
| Particle characteristics | No data available |
| Reactivity | No data available |
| Stability | Stable under recommended storage conditions. |
| Possibility of hazardous reactions | No data available |
| Conditions to avoid | Avoid moisture. no information available |
| Incompatible materials | Strong oxidizing agents |
| Hazardous Polymerization | In the event of fire: see section 5 |
| Acute toxicity | LD50 Oral - Rat - 100.000 mg/kg Remarks: Diarrhea Inhalation: No data available Dermal: No data available |
| Skin corrosion/irritation | Skin - Rabbit Result: No skin irritation |
| Serious eye damage/eye irritation | Eyes - Rabbit Result: No eye irritation |
| Respiratory or skin sensitization | Local lymph node assay (LLNA) - Mouse Result: negative (OECD Test Guideline 429) |
| Carcinogenicity | This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. |
| Germ cell mutagenicity | Ames test Escherichia coli/Salmonella typhimurium Result: negative Remarks: (IUCLID) Mutagenicity (mammal cell test): chromosome aberration. Chinese hamster lung cells Result: negative Remarks: (ECHA) OECD Test Guideline 475 Rat - male - Bone marrow Result: negative |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure | May cause damage to organs through prolonged or repeated exposure. - Kidney |
| Special Remarks on other Toxi Effects on Humans | Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism. |
| Additional Information | RTECS: TR8370000 Unexcreted particles may be phagocytized by cells of the reticuloendothelial system and deposited in storage sites in the liver, spleen, lung, and bone marrow resulting in the storage disease thesaurosis. Severity and symptoms depend on storage site and nature of the particle. Pathological changes are not necessarily attributed to the thesaurosis, but in some cases an inflammation or granulomatoma have occurred. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. |
| Persistence and degradability | No data available |
| Toxicity to fish | LC50 - Danio rerio (zebra fish) - > 1.850 mg/l - 24 h Remarks: (ECHA) |
| Toxicity to daphnia and other aquatic invertebrates | Static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h Remarks: (ECHA) |
| Toxicity to bacteria | EC50 - activated sludge - > 1.000 mg/l - 3 h (OECD Test Guideline 209) Remarks: (IUCLID) |
| Toxicity to algae | ErC50 - Desmodesmus subspicatus (green algae) - ca. 160 mg/l - 4 Days Remarks: (ECHA) |
| Eco Toxicity | Not Available |
| Products Biodegradation | The methods for determining the biological degradability are not applicable to inorganic substances. |
| Mobility in soil | No Information available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | No data available |
| Other adverse effects | No data available |
| Disposal methods | The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. |
| Contaminated packaging | Dispose of as unused product. |
| Waste treatment Method | Offer surplus and non-recyclable solutions to a licensed disposal company. |
| UN number | ADR/RID: IMDG: IATA: |
| UN proper shipping name | ADR/RID: IMDG: IATA: |
| Transport hazard class(es) | ADR/RID: IMDG: IATA: |
| Packaging group | ADR/RID: IMDG: IATA: |
| Environmental hazards | ADR/RID: No IMDG: No IATA: No |
| Special precautions for user | Tunnel restriction code : (C/E) |
| Further information | Not classified as dangerous in the meaning of transport regulations. |
| Transport in bulk according to IMOinstruments | No data available |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
| Safety, health and environmental regulations specific for the product in question | European Inventory of Existing Commercial Chemical Substances (EINECS) -Listed.EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory- Listed. China Catalog of Hazardous chemicals 2015 Not- Listed. New Zealand Inventory of Chemicals (NZIoC)Listed. PICCS -Listed. Vietnam National Chemical Inventory -Listed. IECSC Listed. Korea Existing Chemicals List (KECL) -Listed. |
| National legislation | Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : Not applicable |
| Other regulations | Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. |
| Chemical Safety Assessment | For this product a chemical safety assessment was not carried out |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable. |
Availability
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