THIONYL CHLORIDE FOR SYNTHESIS
- Part number
- RXSOL-60-6605-717
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
Thionyl chloride is mainly used in the industrial production of organochlorine compounds, which are often intermediates in pharmaceuticals and agrichemicals.Mechanism of the Reaction of Alcohols with Thionyl Chloride First, a nucleophilic oxygen atom of the alcohol displaces a chloride ion from thionyl chloride to form a protonated alkyl chlorosulfite intermediate.
Applications
Thionyl chloride is mainly used in the industrial production of organochlorine compounds, which are often intermediates in pharmaceuticals and agrichemicals.
Characteristics and notes
A number of recent reports has described the thionyl chloride mediated oxidation of methylene groups activated by adjacent πaccepting functions. The reaction can follow several pathways according to the structure of the substrate and the amount of thionyl chloride used.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | RXSOL-60-6605-717 |
| Product Type | THIONYL CHLORIDE FOR SYNTHESIS |
| Revised date |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Stock Point : Mumbai, Kandla, Chennai, Visakhapatnam, Kolkata, Fujairah, Muscat Barka
| Phone | +91 22 27815541 / 42 |
| Fax | +91 22 2781 1318 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
Substance / Preparation : Preparation.
Substance name Contents CAS No
Pentasodium (carboxylatomethyl) : -------- 583-61-9
iminobis(ethylenenitrilo) tetraacetate
3.1. Classification of the substance or mixture
Classification EC 67/548 or EC 1999/45
Classification : R14 Xn; R20/22 R29 C; R35
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008
(CLP) Health hazards : Skin corrosion - Category 1A - Danger (CLP : Skin Corr. 1A) H314
Acute toxicity, Oral - Category 4 - Warning (CLP : Acute Tox. 4) H302 Acute toxicity,
Inhalation - Category 4 - Warning (CLP : Acute Tox. 4) H332
3.2. Label elements
Labelling EC 67/548 or EC 1999/45
Symbol(s) : C : Corrosive
R Phrase(s) : R14 : Reacts violently with water.
R20/22 : Harmful by inhalation and if swallowed.
R29 : Contact with water liberates toxic gas.
R35 : Causes severe burns.
S Phrase(s) : S26 : In case of contact with eyes
, rinse immediately with plenty of water and seek medical advice.
S36/37/39 : Wear suitable protective clothing, gloves and eye/face protection.
S45 : In case of accident or if you feel unwell, seek medical advice immediately
( show the label when possible).
Labelling Regulation EC 1272/2008 (CLP)
Hazard pictograms
Signal words : Danger
Hazard statements : H314 : Causes severe skin burns and eye damage.
H302 : Harmful if swallowed.
H332 : Harmful if inhaled. Precautionary statements
• Prevention : P280: Wear protective gloves, protective clothing, eye protection, face protection.
P271: Use only outdoors or in a well-ventilated area.
P260: Do not breathe dust, fume, gas, mist, vapours, spray.
P264: Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
• Response : P301+P330+P331: IF SWALLOWED : Rinse mouth. Do NOT induce vomiting.
P305+P351+P338: IF IN EYES : Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED : Remove to fresh air and keep at rest in a position comfortable for breathing.
P303+P361+P353: IF ON SKIN (or hair) : Remove immediately all contaminated clothing. Rinse skin with water/shower.
P363: Wash contaminated clothing before reuse.
• Storage : P405: Store locked up.
• Disposal considerations : P501: Dispose of this material and its container to hazardous or
special waste collection point, in accordance with local, regional, national and/or international regulation.
3.3. Other hazards
Other hazards : The substance does not fulfil the criteria to be identified as PBT
substance or vPvB substance according to Annex XIII of Regulation REACH.
4.1. Description of first aid measures
Inhalation : Assure fresh air breathing. Allow the victim to rest.
Remove to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTER or doctor. Specific treatment is urgent (see on this label).
Skin contact : Remove affected clothing and wash all exposed
skin area with mild soap and water, followed by warm water rinse.
Immediately call a POISON CENTER or doctor. Specific treatment (see on this label).
Wash with plenty of soap and water. Wash contaminated clothing before reuse.
Remove/Take off immediately all contaminated clothing.
Eye contact : Rinse immediately with plenty of water.
Obtain medical attention if pain, blinking or redness persist. Ingestion : Rinse mouth.
Do NOT induce vomiting. Immediately call a POISON CENTER or doctor. Specific treatment (see on this label).
4.2. Most important symptoms and effects, both acute and delayed
Symptoms relating to use : Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.
4.3. Indication of any immediate medical attention and special treatment needed
General information : Never give anything by mouth to an unconscious person.
If you feel unwell, seek medical advice (show the label where possible).
5.1. Extinguishing media
Suitable extinguishing media : Foam. Dry powder. Carbon dioxide. Water spray. Sand.
Unsuitable extinguishing media : Do not use a heavy water stream.
Surrounding fires : Use water spray or fog for cooling exposed containers.
5.2. Special hazards arising from the substance or mixture
Hazardous combustion products : Under fire conditions, hazardous fumes will be present.
Thermal decomposition generates : Corrosive vapours.
5.3. Advice for fire-fighters
Protection against fire : Do not enter fire area without proper protective equipment,
including respiratory protection.
Special procedures : Exercise caution when fighting any chemical fire.
Avoid (reject) fire-fighting water to enter environment.
6.1. Personal precautions, protective equipment and emergency procedures
For emergency responders : Equip cleanup crew with proper protection. Ventilate area.
For non-emergency personnel : Evacuate unnecessary personnel.
6.2. Environmental precautions
Environmental precautions : Prevent entry to sewers and public waters.
Notify authorities if product enters sewers or public waters.
6.3. Methods and material for containment and cleaning up
Clean up methods : Soak up spills with inert solids, such as clay or diatomaceous
earth as soon as possible. Store away from other materials. Collect spillage.
6.4. Reference to other sections
See section 8. Exposure controls/personal protection
7.1. Precautions for safe handling
Handling : Do not breathe dust, fume, gas, mist, vapours, spray.
Wash contaminated clothing before reuse. Wash thoroughly after handling.
Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area.
Technical protective measures : Provide good ventilation in process area to prevent formation of vapour.
7.2. Conditions for safe storage, including any incompatibilities
Storage : Keep only in the original container in a cool, well ventilated place.
Do not store in corrodable metal.
Keep container tightly closed.
Storage regulation : Comply with applicable regulations.
Storage - away from : Strong bases. Strong acids. Sources of ignition. Direct sunlight.
7.3. Specific end use(s)
Specific end use(s) : None.
8.1. Exposure controls
Personal protection : Avoid all unnecessary exposure.
• Respiratory protection : In case of
insufficient ventilation, wear suitable respiratory equipment.
• Hand protection : Wear protective gloves.
• Skin protection : Wear suitable protective clothing.
• Eye protection : Chemical goggles or face shield.
• Others : When using, do not eat, drink or smoke.
8.2. Control parameters
Occupational Exposure Limits : No data available.
9.1. Information on basic physical and chemical properties
Physical state at 20 °C : Liquid.
Odour : Characteristic, pungent odor
Odour threshold : No data available.
pH value : Not applicable.
Melting point [°C] : -105 °C
Decomposition point [°C] : N/A
Critical temperature [°C] : N/A
Auto-ignition temperature [°C] : N/A
Flammability (solid, gas) : N/A
Flash point [°C] : N/A
Boiling point [°C] : 79 °C
Initial boiling point [°C] : N/A
Final boiling point [°C] : N/A
Evaporation rate : N/A
Vapour pressure [20°C] : 129 hPa at 20 °C
Vapour pressure mm/Hg : N/A
Vapour density : 4,1 Density [g/cm3] : 1,64
Relative density, gas (air=1) : N/A
Relative density, liquid (water=1) : N/A
Solubility in water [% weight] : Decomposes in water
Solubility in water : N/A
Log Pow octanol / water at 20°C : No data available.
Solubility : N/A
Viscosity at 40°C [mm2/s] : N/A
9.2. Other information
Explosive properties : N/A
Explosion limits - upper [%] : N/A
Explosion limits - lower [%] : N/A
Oxidising properties : No data available.
10.1. Reactivity
Reactivity : Not established.
10.2. Chemical stability
Chemical stability : Stable under recommended storage conditions.
10.3. Possibility of hazardous reactions
Hazardous reactions : Not established.
10.4. Conditions to avoid
Conditions to avoid : Direct sunlight. Extremely high or low temperatures.
10.5. Incompatible materials
Materials to avoid : Strong acids. Strong bases.
10.6. Hazardous decomposition products
Hazardous decomposition products : Fumes. Carbon monoxide.
Carbon dioxide. Thermal decomposition generates : Corrosive vapours.
11.1. Information on toxicological effects Acute toxicity
• Inhalation : Based on available data, the classification criteria are not met.
• Dermal : Based on available data, the classification criteria are not met.
• Ingestion : Harmful if swallowed.
Corrosion : Based on available data, the classification criteria are not met.
Irritation : Causes serious eye irritation. Causes skin irritation.
May cause respiratory irritation.
Sensitization : Based on available data, the classification criteria are not met.
Mutagenicity : Based on available data, the classification criteria are not met.
Carcinogenicity : Based on available data, the classification criteria are not met.
Toxic for reproduction : Based on available data, the classification criteria are not met.
STOT-single exposure : Based on available data, the classification criteria are not met.
STOT-repeated exposure : Based on available data, the classification criteria are not met.
Aspiration hazard : Based on available data, the classification criteria are not met.
12.1. Toxicity
Toxicity information : Not established.
12.2. Persistence - degradability
Persistence - degradability : Biodegradable.
12.3. Bioaccumulative potential
Bioaccumulative potential : Not established.
12.4. Mobility in soil
Mobility in soil : Not established.
12.5. Results of PBT and vPvB assessment
Results of PBT and vPvB assessment : The substance does not fulfil the
criteria to be identified as PBT substance or vPvB substance according to Annex XIII of Regulation REACH.
12.6. Other adverse effects
Environmental precautions : Avoid release to the environment.
13.1. Waste treatment methods
General : Avoid release to the environment.
Dispose in a safe manner in accordance with local/national regulations.
Dispose of this material and its container to hazardous or special waste
collection point, in accordance with local, regional, national and/or international regulation.
Special precautions : Do not allow water (or moist air) contact with this material.
14.1. Land transport (ADR-RID)
Proper shipping name : THIONYL CHLORIDE
UN N° : 1836
H.I. nr : X88
ADR - Class : 8
Labelling - Transport : 8 : Corrosive substance.
ADR - Classification code : C1
ADR - Group : I
ADR - Packing instructions : P802
ADR - Limited Quantity : 0
ADR - Tunnel code : E : Passage forbidden through tunnels of category E.
14.2. Sea transport (IMDG) [English only]
Proper shipping name : THIONYL CHLORIDE
UN N° : 1836
IMO-IMDG - Class or division : 8 : Corrosive substance.
IMO-IMDG - Packing group : I
IMO- IMDG - Packing instructions : P802
IMO-IMDG - Limited quantities : None
IMO-IMDG - Marine pollution : No
EMS-Nr : F-A S-B
14.3. Air transport (ICAO-IATA) [English only]
Proper shipping name : THIONYL CHLORIDE
UN N° : 1836
IATA - Class or division : 8 : Corrosive substance.
IATA - Packing group : I
IATA - Passenger and Cargo Aircraft : NOT ALLOWED
IATA - Cargo only : NOT ALLOWED
ERG-Nr : 8W
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Safety, health and environmental : Ensure all national/local regulations are observed.
regulations/legislation specific for the substance or mixture
REACH Restrictions - Annex XVII : The components of this product are not subject to restrictions.
REACH Authorisation - Annex XIV : The components of this product are not subject to authorization.
15.2. Chemical Safety Assessment
Chemical Safety Assessment : It has not been carried out.
Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic. vPvB: very persistent and very bioaccumulative
Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL
of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 Further information : None. In accordance with REACH
Regulation (CE) Nº 1907/2006 and with CLP Regulation (CE) Nº 1272/2008
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
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