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Lab Chemical

THYMIDINE FOR BIOCHEMISTRY 99%

Part number
RXSOL-60-6605-725
Category
Lab Chemical
Brand
RXSOL
RXSOL

Overview

The thymidine analog 5-bromo-2′-deoxyuridine (BrdU) is used to label dividing cells. BrdU is injected intraperitoneally and incorporates into DNA being replicated where it will remain for the life of the cell.

Applications

Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. ... Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA.

Dosage and directions

High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase.

Characteristics and notes

Radioactive labelling techniques are of major importance in the study of DNA synthesis in bacteria. In order to label DNA in Escherichia coli either radioactive thymine or thymidine is generally used because these compounds are specifically incorporated into DNA.

Safety and SDS

Read the safety data sheet before handling. Wear suitable gloves and eye protection.

View safety data sheet
Porduct Name               THYMIDINE FOR BIOCHEMISTRY 99%
Part Number   RX60-6605-725

Company Details:

RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA

Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA  

Phone +91 22 20871200 - 1400
Fax +91 22 27612100 :::AOH :0091 9821214367
Email rxsolchemicals@gmail.com
Website www.rxmraine.com
Chemical Name                 Cas No                        EC No              Whight                          Formula                   

 Thymidine       

50-89-5 200-070-4 242,23 g/mol C10H14N2O5
Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.
Label elements  No hazard pictogram, no signal word, no hazard statement(s), no precautionary statement(s) required
Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
Ecological information The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Toxicological information The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. 
If inhaled After inhalation: fresh air.
Eye Contact  After eye contact: rinse out with plenty of water. Remove contact lenses. 
Swallowed After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
Skin Contact   Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
Most important symptoms and effects, both acute and delaye The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
Suitable extinguishing media  Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given.For this substance/mixture no limitations of extinguishing agents are given.
Special hazards arising from the substance or mixture  Carbon oxides Nitrogen oxides (NOx) Combustible.
Further information Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Advice for firefighters In the event of fire, wear self-contained breathing apparatus.
Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Enviromental Precaution Do not let product enter drains.
Methods and materials for
containment and cleaning
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Reference to other sections    For disposal see section 13.
Precautions for safe handling For precautions see section 2.2.
Storage conditions Tightly closed. Dry.
Storage class Storage class (TRGS 510): 11: Combustible Solids
Specific end     use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Respiratory protection
Required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P1 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Control of    environmental exposure Do not let product enter drains.
Physical state Powder
Colour white
Odour No data available
Odor Threshold Not Applicable
pH No data available
Melting Point Melting point/range: 186 - 188 °C
Boiling Point No data available
Flash Point Not applicable
Flammability (solid, gas) No data available
Explosive limits No Data Available
Upper/lower flammability or explosive limits No data available
Autoignition temperature No data available
Decomposition temperature  No data available
Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available
Density 0,772 g/mL at 25 °C - lit.
Relative Density No data available
Partition coefficient No data available
Explosive properties No data available 
Solubility Soluble
Particle characteristics No data available 
Reactivity                        The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions Violent reactions possible with: Strong oxidizing agents
Conditions to avoid No information available                                            
Incompatible materials
No data available
Hazardous decomposition products In the event of fire: see section 5
Acute toxicity  Oral: No data available  Inhalation : No data available  Dermal : No data available             
Skin corrosion/irritation No data available
Serious eye      damage/irritation No data available 
Respiratory or skin    sensitization  No data available
Carcinogenicity No data available
Germ cell        mutagenicity  Test Type :  Mouse Test  system : fibroblast  Remarks : Unscheduled DNA synthesis
Reproductive toxicity  No data available
Specific target organ toxicity - single      exposure
No data available
Additional Information RTECS: XP2071000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated
Persistence and degradability No data available
Toxicity No data available
 Bioaccumulative potential Static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 74,35 mg/l - 72 h (OECD Test Guideline 201) Remarks: (in analogy to similar products) The value is given in analogy to the following substances: maleic acid
Mobility in soil No data available
Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Endocrine disrupting       properties The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Other adverse effects No data available .
Waste treatment  Method No data available
UN number ADR/RID: -             IMDG: -                IATA: -
UN proper shipping name  ADR/RID: Not dangerous goods        IMDG: Not dangerous goods  IATA: Not dangerous goods 
Transport hazard class(es)      ADR/RID : -             IMDG :  -             IATA : -
Packaging group ADR/RID : -             IMDG :  -             IATA :  -
Environmental hazards ADR/RID: No                IMDG Marine pollutant: No                  IATA: No
Special precautions for user No data available
Further information Not classified as dangerous in the meaning of transport regulations.
Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.
Chemical Safety Assessment For this product a chemical safety assessment was not carried out
Other Information

The information above is believed to be accurate and represents the  best information   currently    available  to us.  However,   we   make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and  weassume  no liability resulting from its use. Users should make  their  own  investigations  to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International  has been advised of the possibility of such damages.

DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.

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Availability

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