Tert BUTYLDIMETHYLSILYL CHLORIDE FOR SYNTHESIS
- Part number
- RXSOL-60-6605-663
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
Tert BUTYLDIMETHYLSILYL CHLORIDE FOR SYNTHESIS is used to protect alcohols in organic synthesis. Examples can be found in the Nicolaou taxol total synthesis
Applications
The compound is used to protect alcohols in organic synthesis. Examples can be found in the Nicolaou taxol total synthesis. tert-Butyldimethylsilyl chloride reacts with alcohols in the presence of base to give tert-butyldimethylsilyl
Characteristics and notes
tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula Me₂SiCl. It is commonly abbreviated as TBSCl or TBDMSCl. It is a silane containing two methyl groups, a tert-butyl group, and a reactive chloride.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | Tert BUTYLDIMETHYLSILYL CHLORIDE FOR SYNTHESIS |
| Part Number | RXSOL-60-6605-663 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com | |
| Website | www.rxmraine.comA |
| Chemical Name | CAS | EC number | Weight | Formula |
| Tert.-butylchlorodimethylsilane | 18162-48-6 | 242-042-4 | <= 100 % | C6H15ClSi |
| Signal Word | Danger |
| Hazard Statements | H228 Flammable solid. H314 Causes severe skin burns and eye damage. H411 Toxic to aquatic life with long lasting effects. |
| Precautionary statements | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P260 Do not breathe dusts or mists. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Classification of the substance or mixture | Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008. |
| Supplemental Hazard Statements | None. |
| Other hazards | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| General advice | First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance. |
| If inhaled | After inhalation: fresh air. Call in physician. |
| Eye Contact | After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses. |
| Swallowed | After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise. |
| Skin Contact | In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately. |
| Inhalation | Remove patient to fresh air, keep warm and at rest and get medical assistance in necessary. |
| Ingestion | Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately. |
| Most important symptoms and effects, both acute and delaye | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Flammability | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
| Suitable extinguishing media | Carbon dioxide (CO2) Dry powder |
| Unsuitable extinguishing media | Foam Water |
| Special hazards arising from the substance or mixture | Carbon oxides Hydrogen chloride gas silicon oxides Combustible. Fire may cause evolution of: Hydrogen chloride gas Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. |
| Further information | Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system. |
|
Hazardous combustion products |
Fire may cause the evolution of Sulphur oxides, nitrogen oxides. |
| Advice for firefighters | Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. |
| Protective Equipment | Use personal protective equipment. |
| Specific Hazards Arising from the Chemical | Oxides of phosphorus Sodium oxides Not combustible. Fire may cause evolution of: Oxides of phosphorus Ambient fire may liberate hazardous vapours. |
| Personal precautions, protective equipment and emergency procedures | Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. |
| Spillage | Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal. |
| Enviromental Precaution | Do not let product enter drains. Risk of explosion. |
|
Methods and materials for containment and cleaning |
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts. |
| Advice on protection against fire and explosion | Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. |
| Incompatible materials | Keep away from alkalis, strong oxidizing agents and metals. Provide containment walls of adequate capacity to hold any accidental spills. |
| Hygiene measures | Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. |
| Precautions for safe handling | For precautions see section 2.2. |
| Storage conditions | Tightly closed. Keep away from heat and sources of ignition. Recommended storage temperature see product label. |
| Storage class | Storage class (TRGS 510): 10: Combustible liquids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| Advice on general occupational hygiene | Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance. |
| Requirements for storage | Keep in cool and store under shade. |
| Exposure controls | Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. |
| Control parameters | Ingredients with workplace control parameters Contains no substances with occupational exposure limit values. |
| Engineering Control | Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. |
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles |
| Body Protection | Flame retardant antistatic protective clothing. |
| Skin protection | This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L |
| Respiratory protection | Required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P2 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. |
| Other Protection Measure | Handle in accordance with good industrial hygiene and safety practice. |
| Control of environmental exposure | Do not let product enter drains. Risk of explosion. |
| Physical state | Crystals |
| Colour | Colorless |
| Odour | No data available |
| Odor Threshold | No data available |
| pH | No data available |
| Melting Point | 90,1 - 93,4 °C at 1.013 |
| Boiling Point | 126,1 °C at 1.030 hPa |
| Flash Point | 22 °C - c.c. |
| Evaporation Rate | Not Applicable |
| Flammability (solid, gas) | No data available |
| Explosive limits | No Data Available |
| Upper/lower flammability or explosive limits | No data available |
| Autoignition temperature | No data available |
| Decomposition temperature | No data available |
| Vapour pressure | 7,10 hPa at 25 °C |
| Density | 0,94 g/cm3 at 20 °C |
| Relative Density | No data available |
| Relative vapor density | No data available |
| Freezing point | No data available |
| Viscosity | No data available |
| Partition coefficient | No data available |
| Explosive properties | No data available |
| Solubility | No data available |
| Ignition temperature | No information available. |
| Particle characteristics | No data available |
| Reactivity | The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. |
| Stability | The product is chemically stable under standard ambient conditions (room temperature) . |
| Possibility of hazardous reactions | Exothermic reaction with: Generates dangerous gases or fumes in contact with: Water alkalines Strong oxidizing agents Alcohols Metals Violent reactions possible with: The generally known reaction partners of water. |
| Conditions to avoid | Exposure to moisture. no information available |
| Incompatible materials | No data available |
| Hazardous decomposition products | In the event of fire: see section 5 |
| Acute toxicity | Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach. LD50 Oral - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 423) Inhalation: No data available Dermal: No data available |
| Skin corrosion/irritation | Skin - Rabbit Result: Corrosive - 4 h (OECD Test Guideline 404) |
| Serious eye damage/eye irritation | Remarks: Causes serious eye damage. |
| Respiratory or skin sensitization | Maximization Test - Guinea pig Result: negative (OECD Test Guideline 406) |
| Toxic Effects on Human | May cause damage to the following organs: upper respiratory tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant, lung sensitizer). |
| Carcinogenicity | No data available |
| Germ cell mutagenicity | Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster fibroblasts Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473 Result: positive Test Type: In vitro mammalian cell gene mutation test Test system: mouse lymphoma cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 490 Result: negative Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster fibroblasts Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 487 Result: negative |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure | Inhalation - May cause respiratory irritation. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Quantitative data on the toxicity of this product are not available. Further data: Other dangerous properties can not be excluded. Handle in accordance with good industrial hygiene and safety practice. |
| Bioaccumulative potential | Bioaccumulation Cyprinus carpio (Carp) - 41 d at 20 °C(Silver nitrate) Bioconcentration factor (BCF): 70 |
| Persistence and degradability | Biodegradability aerobic - Exposure time 28 d Result: 81 % - Readily biodegradable. (OECD Test Guideline 301F) |
| Toxicity to fish | Flow-through test LC50 - Gambusia affinis (Mosquito fish) - 8.510 mg/l - 96 h (OECD Test Guideline 203) |
| Toxicity to daphnia and other aquatic invertebrates | Static test EC50 - Daphnia magna (Water flea) - 6,49 mg/l - 48 h (OECD Test Guideline 202) |
| Toxicity to algae | ErC50 - Pseudokirchneriella subcapitata (green algae) - 84 mg/l - 72 h (OECD Test Guideline 201) NOEC - Pseudokirchneriella subcapitata (green algae) - 12,5 mg/l - 72 h (OECD Test Guideline 201) |
| Toxicity to bacteria | EC50 - Photobacterium phosphoreum - 3.070 mg/l - 5 min Remarks: (IUCLID) |
| Mobility in soil | No Information available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. |
| Other adverse effects | We have no quantitative data concerning the ecological effects of this product. Further information on ecology Discharge into the environment must be avoided. |
| Disposal methods | The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. |
| Contaminated packaging | Dispose of as unused product. |
| Waste treatment Method | No data available |
| UN number | ADR/RID:2925 IMDG: 2925 IATA:2925 |
| UN proper shipping name |
ADR/RID:Flammable solid, corrosive, organic, n.o.s. (tert.-butylchlorodimethylsilane) IMDG:Flammable solid, corrosive, organic, n.o.s. (tert.-butylchlorodimethylsilane) IATA:Flammable solid, corrosive, organic, n.o.s. (tert.-butylchlorodimethylsilane) |
| Transport hazard class(es) | ADR/RID:4.1 (8) IMDG:4.1 (8) IATA:4.1 (8) |
| Packaging group | ADR/RID: II IMDG: II IATA: II |
| Environmental hazards | ADR/RID: NO IMDG: NO IATA: NO |
| Further information | No data available |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
| Chemical Safety Assessment | For this product a chemical safety assessment was not carried out |
| National legislation | Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ENVIRONMENTAL HAZARDS |
| Other regulations | Take note of Dir 94/33/EC on the protection of young people at work. |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable. |
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