b-CYCLODEXTRIN
- Part number
- RXSOL-60-6604-028
- Category
- Lab Chemical
- Brand
- RXSOL
Overview
b- cyclodexrin pharmaceutical industry,
cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility
of active substances poorly soluble in water, in order to increase their bioavailability and to improve stability.
Technical specifications
Melting point/freezing point
| Odour Threshold | No data available |
|---|---|
| pH | No data available |
| Melting point/range | 90 - 300 °C |
| Initial boiling point and boiling range | No data available |
| Flash point | No data available |
| Evaporation rate | No data available |
| Flammability (solid, gas) | No data available |
| Upper/lower flammability or explosive limits | No data available |
| Vapour pressure | No data available |
| Vapour density | No data available |
Relative density 1.44 g/cm3 at 20 °C
| Water solubility 14.3 g/l at 20 °C | soluble |
|---|---|
| Partition coefficient | noctanol/ water : No data available |
| Auto-ignition temperature | No data available |
| Decomposition temperature | >250 °C |
| Viscosity | No data available |
| Explosive properties | No data available |
| Oxidizing properties | No data available |
Other safety information
| Bulk density 4 | 700 kg/m3 |
|---|
Applications
β-Cyclodextrin is used as a complexing agent in drug delivery because it forms an inclusion complex with a drug molecule.
Dosage and directions
b-CYCLODEXTRIN Increasing the dose to either 4000 mg/kg weekly or every other day delayed clinical disease onset, increased survival time, corrected cholesterol.
Characteristics and notes
β-Cyclodextrin (β-CD) is a cone-shaped molecule. It is hydrophilic at the outer surface of the cavity for many hydroxyl groups, but hydrophobic in the cavity.
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | RXSOL-60-6604-028 |
| Product Type | β - CYCLODEXTRIN |
| Revised date |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Stock Point : Mumbai, Kandla, Chennai, Visakhapatnam, Kolkata, Fujairah, Muscat Barka
| Phone | +91 22 27815541 / 42 |
| Fax | +91 22 2781 1318 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com |
3.1 Substances : β - Cyclodextrin
CAS-No. : 7585-39-9
Substance.
Contains no other components or impurities which will influence the classification of the
product.
2.1 Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.2 Label elements
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB)
at levels of 0.1% or higher.
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist
or gas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials
for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in
suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage class (TRGS 510): Non Combustible Solids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal
technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good
laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of
dangerous substances, and to the specific work-place., The type of protective equipment
must be selected according to the concentration and amount of the dangerous substance at
the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance le (EN 143) dust
masks. Use respirators and components tested and approved under appropriate
government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.
9.1 Information on basic physical and chemical properties
Odour Threshold : No data available
pH : No data available
Melting point/freezing point
Melting point/range: 290 - 300 °C
Initial boiling point and boiling range : No data available
Flash point : No data available
Evaporation rate : No data available
Flammability (solid, gas) : No data available
Upper/lower flammability or explosive limits : No data available
Vapour pressure : No data available
Vapour density: No data available
Relative density 1.44 g/cm3 at 20 °C
Water solubility 14.3 g/l at 20 °C: - soluble
Partition coefficient: noctanol/ water : No data available
Auto-ignition temperature : No data available
Decomposition temperature : > 250 °C
- Viscosity : No data available
Explosive properties :No data available
Oxidizing properties: No data available
9.2 Other safety information
Bulk density 400 - 700 kg/m3
Burning rate < 0.25 mm/s
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - No data available
In the event of fire: see section 5
11.1 Information on toxicological effects Acute toxicity
LD50 Oral - Rat - male and female - > 5,000 mg/kg(β-Cyclodextrine)
(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - >= 4.9 mg/l(β-Cyclodextrine)
(OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 2,000 mg/kg(β-Cyclodextrine)
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin -Rabbit (β-Cyclodextrine)
Result: No skin irritation - 24 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit(β-Cyclodextrine)
Result: Mild eye irritation
(OECD Test Guideline 405)
Respiratory or skin sensitisation
Maximisation Test - Guinea pig(β-Cyclodextrine)
Result: Does not cause skin sensitisation.
(OECD Test Guideline 406)
Germ cell mutagenicity
Tests on bacterial or mammalian cell cultures did not show mutagenic effects.(βCyclodextrine)
Hamster(β-Cyclodextrine)
Lungs
Result: negative
OECD Test Guideline 477(β-Cyclodextrine)
Drosophila melanogaster - male and female
Result: negative
Carcinogenicity
Animal testing did not show any carcinogenic effects.(β-Cyclodextrine)
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Specific target organ toxicity - single exposure
No data available(β-Cyclodextrine)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available(β-Cyclodextrine)
Additional Information
Repeated dose toxicity - Rat - male - Oral - No observed adverse effect level - 650
mg/kg(β-Cyclodextrine)
Repeated dose toxicity - Rat - female - Oral - No observed adverse effect level - 860
mg/kg(β- Cyclodextrine)
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have
not been thoroughly investigated.(β-Cyclodextrine)
12.1 Toxicity
Toxicity to fish static test LC50 - Cyprinus carpio (Carp) - 7,561 mg/l - 96 h(β
Cyclodextrine)
(OECD Test Guideline 203)
Toxicity to daphnia and other aquatic invertebrates
Immobilization EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h(β
Cyclodextrine)
(OECD Test Guideline 202)
Toxicity to algae Growth inhibition IC50 - Desmodesmus subspicatus (green algae) - >
100 mg/l - 72 h(β-Cyclodextrine)
(OECD Test Guideline 201)
Toxicity to bacteria Cell multiplication inhibition test EC50 - Pseudomonas putida - >
10,000 mg/l - 16 h(β-Cyclodextrine)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d(β-Cyclodextrine)
Result: 75 % - Readily biodegradable
(OECD Test Guideline 301F)
Biochemical Oxygen
Demand (BOD)
700 mg/g(β-Cyclodextrine)
Chemical Oxygen
Demand (COD)
1,090 mg/g(β-Cyclodextrine)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available(β-Cyclodextrine)
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent ,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Additional ecological information No data available
13.1 Waste treatment methods Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve
or mix the material with a combustible solvent and burn in a chem scrubber.
Contaminated packaging
Dispose of as unused product.
14.1 UN number
ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
14.4 Packaging group
ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
ADR - Packing instructions : P001
ADR - Limited Quantity : 1 L
ADR - Tunnel code : D/E : Bulk or tank carriage: Passage forbidden through tunnels of
category D and
E. Other carriage: Passage forbidden through tunnels of category E.
14.2. Sea transport (IMDG) [English only]
Proper shipping name : ACETIC ACID,
UN N° : 2789
IMO-IMDG - Class or division : 8 : Corrosive substance. ( 3 : Flammable liquid. )
IMO-IMDG - Packing group : II
IMO- IMDG - Packing instructions : P001
IMO-IMDG - Limited quantities : 1 L
IMO-IMDG - Marine pollution : No
EMS-Nr : F-E S-C
14.3. Air transport (ICAO-IATA) [English only]
Proper shipping name : ACETIC ACID
UN N° : 2789
IATA - Class or division : 8 : Corrosive substance. ( 3 : Flammable liquid. )
IATA - Packing group : II
IATA - Passenger and Cargo Aircraft : ALLOWED
- Passenger and Cargo - Packing : 851
instruction
- Passenger and Cargo - Maximum : 1 L
Quantity/Packing
IATA - Cargo only : ALLOWED
- Cargo only - Packing instruction : 855
- Cargo only - Maximum Quantity/ : 30 L
Packing
IATA - Limited Quantites : 0.5 L
ERG-Nr : 8F
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out
Abbreviations and acronyms : PBT: persistent, bioaccumulative and toxic.
vPvB: very persistent and very bioaccumulative
Sources of key data used : REGULATION (EC) No 1272/2008 OF THE EUROPEAN
PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification,
labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Further information : None.
In accordance with REACH Regulation (CE) Nº 1907/2006 and with CLP Regulation
(CE) Nº 1272/2008
DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.
Availability
b-CYCLODEXTRIN manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman.
Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada.
b-CYCLODEXTRIN is available in small packing as well as in bulk. Buy premium quality b-CYCLODEXTRIN and other lab chemicals from one of the most trusted brands.
